{"id":"W2342976696","doi":"10.1073/pnas.1524291113","title":"Importin 8 mediates m <sup>7</sup> G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; National Institute of General Medical Sciences; Canada Research Chairs; Leukemia and Lymphoma Society","keywords":"EIF4E; Importin; Nuclear export signal; Nuclear transport; Initiation factor; Eukaryotic translation; Nucleoplasm; Eukaryotic initiation factor; Biology; Nuclear localization sequence; Cell biology; Cancer research; Translation (biology); Cell nucleus; Cytoplasm; Messenger RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742844,0.0002760616,0.0002233393,0.00009828761,0.0001984945,0.0002097348,0.0001830017,0.0001786079,0.001602237],"category_scores_gemma":[0.0002340986,0.0001301762,0.0002771179,0.00005663397,0.0001761435,0.0001856859,0.000372236,0.0003654285,0.0008281115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859233,"about_ca_system_score_gemma":0.0001466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004033064,"about_ca_topic_score_gemma":0.0005884416,"domain_scores_codex":[0.9998844,0.00002244985,0.00001081703,0.00002244389,0.00002384874,0.00003607566],"domain_scores_gemma":[0.9998938,0.00002511012,0.00003080419,0.00001434683,0.00001604123,0.00001996007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003141412,0.00003586153,0.0003504525,0.0000727048,0.000005390812,0.0001598415,0.00003659046,0.00009867834,0.9961063,0.0001908301,0.0001614191,0.002467752],"study_design_scores_gemma":[0.00003221625,0.0002385187,0.004643881,0.00001259894,0.000007169821,0.000550141,0.00004363708,0.001468846,0.9869321,0.0001016222,0.005963333,0.000005833768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903646,0.002442429,0.00338567,0.0002117314,0.00006326701,0.0000419481,0.0001683536,0.0001384889,0.003183494],"genre_scores_gemma":[0.9932066,0.0008421564,0.001918054,0.00008111882,0.00002174794,0.00003176756,0.0004846858,0.00003030831,0.003383539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602237,"threshold_uncertainty_score":0.005360007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03310024624262096,"score_gpt":0.2862925792279434,"score_spread":0.2531923329853225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}