{"id":"W2342979891","doi":"10.1186/s13024-016-0103-6","title":"A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease","year":2016,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Research Resources; NIH Clinical Center; National Institute on Aging; National Institutes of Health; Alzheimer's Drug Discovery Foundation","keywords":"Disease; Neurology; Medicine; Neuroscience; Molecular medicine; Human genetics; Bioinformatics; Biology; Pathology; Genetics; Gene; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045825,0.001202914,0.0004826553,0.0009602376,0.000307646,0.0004113174,0.0005434083,0.0008727213,0.001357131],"category_scores_gemma":[0.0001247203,0.0002873747,0.0006573328,0.0002756034,0.0005755561,0.0003978126,0.0003793607,0.001241945,0.0003288544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004734944,"about_ca_system_score_gemma":0.0003882217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006108624,"about_ca_topic_score_gemma":0.001173351,"domain_scores_codex":[0.9997573,0.00004037974,0.00002200401,0.00006574124,0.00006683137,0.00004762259],"domain_scores_gemma":[0.999862,0.00001156213,0.00004657156,0.0000262235,0.00001853984,0.000035058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001702521,0.0001323581,0.00008021345,0.00005782315,0.00001319973,0.0001108964,0.00001792975,0.00008172744,0.9962089,0.0004978077,0.0001010522,0.002527799],"study_design_scores_gemma":[0.0002102632,0.003876342,0.002628889,0.00004935407,0.0001114436,0.0014365,0.00003578822,0.001391494,0.9794379,0.0003973864,0.01040453,0.00002008313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9555548,0.004932841,0.03247971,0.0008532114,0.0002392453,0.0004285191,0.0008625314,0.0008475855,0.003801697],"genre_scores_gemma":[0.9614109,0.004163216,0.02646151,0.0002241076,0.00006252416,0.0005299494,0.0007331013,0.00007058094,0.006344103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357131,"threshold_uncertainty_score":0.004540086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0991082754338909,"score_gpt":0.2966397232328832,"score_spread":0.1975314477989923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}