{"id":"W2343174409","doi":"10.1186/s12977-016-0265-x","title":"Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses","year":2016,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Integrase; Virology; Dolutegravir; Viral replication; Reverse transcriptase; Mutant; Biology; Mutation; Resistance mutation; Plasmid; Integrase inhibitor; Virus; Viral load; DNA; Human immunodeficiency virus (HIV); Genetics; Polymerase chain reaction; Gene; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003908322,0.0007275084,0.0005177127,0.000346741,0.000190238,0.0004283883,0.0004218189,0.0004301928,0.002421013],"category_scores_gemma":[0.0004343228,0.0002024367,0.000463939,0.0002684414,0.0003105522,0.0002554895,0.0002823216,0.0007954555,0.0005967089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004076924,"about_ca_system_score_gemma":0.0002113523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003013,"about_ca_topic_score_gemma":0.000970343,"domain_scores_codex":[0.9995189,0.0001068956,0.00006466018,0.00009892333,0.0001298068,0.00008086648],"domain_scores_gemma":[0.9995952,0.0001288958,0.0001092532,0.00004853505,0.00004195454,0.00007614648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004361639,0.0002183545,0.0007085018,0.00007771084,0.00002964845,0.00005507829,0.00002712573,0.0003933224,0.9954216,0.00005612033,0.00007217726,0.002504089],"study_design_scores_gemma":[0.00003481557,0.002174611,0.004671621,0.00001629018,0.00005326409,0.0002418596,0.00002592117,0.001956499,0.989404,0.0000283454,0.001377744,0.00001510477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970735,0.0006689477,0.0005917546,0.00003166135,0.00002761858,0.0000320254,0.0005132437,0.00005534971,0.001005946],"genre_scores_gemma":[0.9948442,0.0003814947,0.002323535,0.00003733662,0.000009097126,0.00003868534,0.0009580652,0.00005528392,0.001352229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002421013,"threshold_uncertainty_score":0.008099139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01733287712530532,"score_gpt":0.2837089153130701,"score_spread":0.2663760381877648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}