{"id":"W2343202094","doi":"10.1074/jbc.m116.731398","title":"E2 Ubiquitin-conjugating Enzyme, UBE2C Gene, Is Reciprocally Regulated by Wild-type and Gain-of-Function Mutant p53","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Bangladesh Council of Scientific and Industrial Research; Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Anaphase; Anaphase-promoting complex; Cell biology; Mitosis; Securin; Biology; Chromosome instability; Spindle checkpoint; Ubiquitin; Mutant; Genome instability; Spindle apparatus; Genetics; Cell cycle; Cell division; DNA damage; Gene; DNA; Chromosome; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222227,0.0006357508,0.000234243,0.0004298474,0.0001989652,0.0003992213,0.0002145479,0.0003144901,0.0009414048],"category_scores_gemma":[0.000187945,0.0002181414,0.0002175652,0.0002501379,0.0003679647,0.0001606236,0.0002535426,0.0003959596,0.0003346992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005141851,"about_ca_system_score_gemma":0.0002173504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005642941,"about_ca_topic_score_gemma":0.0007397323,"domain_scores_codex":[0.99977,0.00002302646,0.00001821079,0.00006259574,0.00007086468,0.00005527438],"domain_scores_gemma":[0.9998558,0.00002407651,0.00004919136,0.00002073786,0.00001701645,0.00003313445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008284858,0.00001599262,0.0003719755,0.00001371832,0.000003931203,0.0001163123,0.000005610284,0.00004693949,0.9984779,0.0001125006,0.00002763343,0.0007247238],"study_design_scores_gemma":[0.00002268576,0.00009299716,0.01143623,0.000005290332,0.00001949668,0.0006725086,0.00002495905,0.001919598,0.983215,0.0001158021,0.002470344,0.000005076032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936718,0.001506114,0.00278992,0.0001122462,0.00003399643,0.00002288435,0.000398005,0.0001663341,0.001298589],"genre_scores_gemma":[0.9968799,0.0003517232,0.0006607126,0.00002306902,0.000004514311,0.00002055362,0.0003035828,0.0000146414,0.001741325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009414048,"threshold_uncertainty_score":0.003730655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097649796971558,"score_gpt":0.2286851983267784,"score_spread":0.2177087003570628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}