{"id":"W2343285928","doi":"10.1007/s11538-016-0161-5","title":"Feedback Regulation in a Cancer Stem Cell Model can Cause an Allee Effect","year":2016,"lang":"en","type":"article","venue":"Bulletin of Mathematical Biology","topic":"Mathematical Biology Tumor Growth","field":"Mathematics","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Biomedical Imaging and Bioengineering; National Science Foundation; National Institutes of Health; National Cancer Institute; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Allee effect; Extinction (optical mineralogy); Biology; Cancer; Stem cell; Cell biology; Medicine; Genetics; Population; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004972054,0.0006042016,0.000656559,0.0005038917,0.0005944184,0.001014171,0.0007833544,0.001446853,0.005688782],"category_scores_gemma":[0.002080763,0.0002240271,0.0006849291,0.0002844401,0.0009855302,0.0008880757,0.001016425,0.0009876686,0.000291018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005860927,"about_ca_system_score_gemma":0.0007586571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00191339,"about_ca_topic_score_gemma":0.001452118,"domain_scores_codex":[0.99981,0.0000750652,0.000005517103,0.00003158848,0.00003827076,0.00003959526],"domain_scores_gemma":[0.9992487,0.0003846791,0.0001013147,0.00006706104,0.00009072856,0.0001074383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002449171,0.0001417595,0.001303526,0.000139892,0.00007751696,0.0006071454,0.0002138967,0.3254881,0.02652921,0.634004,0.003465858,0.00778416],"study_design_scores_gemma":[0.00009854507,0.0001381406,0.0006051515,0.0000137144,0.00006635951,0.0001433206,0.00007568773,0.8294507,0.002914126,0.1645428,0.001920286,0.00003118507],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.619233,0.0008145031,0.2983041,0.00588451,0.0004879537,0.00009243735,0.0004456814,0.0007499663,0.07398783],"genre_scores_gemma":[0.9833549,0.0001944287,0.003972427,0.0002035245,0.00004367549,0.00004327452,0.0000340289,0.00003169037,0.01212213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005688782,"threshold_uncertainty_score":0.01903087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04378508260500066,"score_gpt":0.3104073317946487,"score_spread":0.2666222491896481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}