{"id":"W2343333252","doi":"10.1186/s40478-016-0313-8","title":"ALS-linked misfolded SOD1 species have divergent impacts on mitochondria","year":2016,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health Research Institute; Vancouver Coastal Health; University of Waterloo; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; Muscular Dystrophy Association; Fondation Brain Canada; ALS Society of Canada","keywords":"SOD1; Mitochondrion; Cell biology; Protein folding; Amyotrophic lateral sclerosis; Chemistry; Biochemistry; Biology; Superoxide dismutase; Medicine; Pathology; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000300133,0.0002709462,0.0003820265,0.0001618673,0.0004554007,0.00005170543,0.001259188,0.0001474058,0.0009191613],"category_scores_gemma":[0.001741617,0.000155286,0.0001976395,0.0002513202,0.0005848119,0.0001384171,0.001038878,0.0005093342,0.0007333626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001694342,"about_ca_system_score_gemma":0.00007000514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001899024,"about_ca_topic_score_gemma":0.00001353808,"domain_scores_codex":[0.9974047,0.0006583972,0.0004343088,0.0004623156,0.0004914138,0.0005488881],"domain_scores_gemma":[0.9948322,0.0008076356,0.0001597471,0.003606714,0.0002326916,0.0003609674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002039108,0.0006375198,0.01370069,0.000009242105,0.00003489056,0.00009447149,0.0002005044,5.782506e-7,0.9734696,0.0009628006,0.007754192,0.002931594],"study_design_scores_gemma":[0.001465842,0.0008988847,0.9262607,0.0001724087,0.00005266517,0.00009527444,0.00004375893,0.00004084675,0.003938052,0.0002669409,0.06652711,0.0002375577],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9014334,0.0001914914,0.00005012432,0.08195405,0.000141587,0.0008710215,0.000064127,0.0002680604,0.01502612],"genre_scores_gemma":[0.9841632,0.006024437,0.001248181,0.001859711,0.0001144273,0.0001080067,0.00004413469,0.00004218413,0.006395723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9695315,"threshold_uncertainty_score":0.9999942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1201878837797307,"score_gpt":0.3404441756884811,"score_spread":0.2202562919087505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}