{"id":"W2343386476","doi":"10.1056/nejmoa1516282","title":"Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma","year":2016,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1054,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary; Hotel Dieu Hospital","funders":"Takeda Oncology","keywords":"Lenalidomide; Ixazomib; Medicine; Multiple myeloma; Dexamethasone; Oncology; Internal medicine; Dermatology; Pharmacology; Carfilzomib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107806,0.0001778066,0.0006475345,0.0002496955,0.00005807609,0.000008547043,0.00009032714,0.00007108964,0.0002160358],"category_scores_gemma":[0.003812312,0.00008197696,0.00009891432,0.0001039889,0.0001780629,0.0001240628,0.00002443571,0.0001611782,0.000005827524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006968217,"about_ca_system_score_gemma":0.0001876564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000752414,"about_ca_topic_score_gemma":0.00005110226,"domain_scores_codex":[0.9984388,0.00008184713,0.0004937832,0.0001728817,0.0004804825,0.0003322569],"domain_scores_gemma":[0.997041,0.001468252,0.0002234458,0.0001695554,0.0003268123,0.0007709039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01083302,0.00009609279,0.09096467,0.00006314233,0.0003667243,0.0003582969,0.0002126535,3.048773e-7,0.03989277,0.00008061927,0.009126024,0.8480057],"study_design_scores_gemma":[0.6243415,0.01098499,0.1691242,0.001718582,0.0006149394,0.00525324,0.0001612876,0.0001483198,0.01301766,0.002010656,0.172393,0.0002315415],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96096,0.002819444,0.00915232,0.02589359,0.0003332306,0.0004785547,0.00001294305,0.0000162147,0.0003336441],"genre_scores_gemma":[0.9855336,0.0009452556,0.008655086,0.000319945,0.002719529,0.000005786466,0.000004785454,0.00002534753,0.001790671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8477741,"threshold_uncertainty_score":0.4563969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05120611506231794,"score_gpt":0.3360375626803982,"score_spread":0.2848314476180803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}