{"id":"W2343417001","doi":"10.1021/acs.jmedchem.6b00211","title":"The Identification and Pharmacological Characterization of 6-( <i>tert</i> -Butylsulfonyl)- <i>N</i> -(5-fluoro-1 <i>H</i> -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ryerson University; Northwestern University; GlaxoSmithKline","keywords":"Chemistry; NOD1; NOD2; Kinase; Innate immune system; Signal transduction; In vivo; Ex vivo; In vitro; Drug discovery; Cell biology; Receptor; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756228,0.0002769114,0.0002232633,0.0001194559,0.00009715024,0.0001791622,0.0001937582,0.0002459825,0.001047807],"category_scores_gemma":[0.0001268821,0.00007411015,0.0002309934,0.00009122002,0.0001714638,0.0001842483,0.0001208375,0.0004539163,0.0004803897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209185,"about_ca_system_score_gemma":0.0002511116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002763894,"about_ca_topic_score_gemma":0.0005479719,"domain_scores_codex":[0.9999529,0.000007764054,0.000004565218,0.00000899379,0.0000110879,0.00001472877],"domain_scores_gemma":[0.9999609,0.000006711347,0.0000113666,0.000004993432,0.000005477574,0.00001061475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00011661,0.00005543446,0.00009680755,0.00006624298,0.000006563837,0.00009536552,0.00001325981,0.0001302236,0.9956009,0.0001713872,0.00009676935,0.003550344],"study_design_scores_gemma":[0.0001692682,0.001717539,0.002668231,0.00001001821,0.00003052454,0.0006429499,0.00001588987,0.0008468008,0.9892349,0.0001324322,0.004522607,0.000008917302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764599,0.006682345,0.008337857,0.0004669883,0.00007534034,0.0001830258,0.001100706,0.00009950637,0.006594361],"genre_scores_gemma":[0.9875529,0.003424883,0.00485773,0.0001805168,0.00002601303,0.00008270282,0.001070987,0.00001349281,0.002790659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047807,"threshold_uncertainty_score":0.00350529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00582530766602662,"score_gpt":0.2270282331524517,"score_spread":0.2212029254864251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}