{"id":"W2343417001","doi":"10.1021/acs.jmedchem.6b00211","title":"The Identification and Pharmacological Characterization of 6-( <i>tert</i> -Butylsulfonyl)- <i>N</i> -(5-fluoro-1 <i>H</i> -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ryerson University; Northwestern University; GlaxoSmithKline","keywords":"Chemistry; NOD1; NOD2; Kinase; Innate immune system; Signal transduction; In vivo; Ex vivo; In vitro; Drug discovery; Cell biology; Receptor; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007247634,0.0001649284,0.0003933272,0.00005644604,0.0001003669,0.000009370366,0.0001875006,0.000182908,0.00003405672],"category_scores_gemma":[0.0002565267,0.00008913716,0.00008444362,0.00008184123,0.000600593,0.0001160512,0.00006930783,0.0002793313,0.000002013608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004777155,"about_ca_system_score_gemma":0.000110747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003102688,"about_ca_topic_score_gemma":2.460323e-7,"domain_scores_codex":[0.9984689,0.0001569483,0.0008898475,0.0001596144,0.0001233149,0.0002013958],"domain_scores_gemma":[0.9980781,0.000335078,0.001039772,0.0001205247,0.0003781704,0.00004835373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002845609,0.0001383992,0.000329686,0.00007220649,0.0002013196,0.000009905333,0.000179318,4.128064e-8,0.9794348,0.00001083082,0.0005159322,0.01626188],"study_design_scores_gemma":[0.002618156,0.0006080936,0.006264833,0.0002910173,0.0001716467,0.0007930578,0.0001804989,0.000001023053,0.9844717,0.00002791539,0.004479768,0.00009224245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932536,0.004080221,0.0002084753,0.001856356,0.0003763681,0.0001104529,0.00003428129,0.000006437046,0.00007381612],"genre_scores_gemma":[0.9958382,0.003191678,0.00001257736,0.00008944329,0.000125309,0.00000444554,0.000008048166,0.000009469556,0.0007208882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01616963,"threshold_uncertainty_score":0.3634908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00582530766602662,"score_gpt":0.2270282331524517,"score_spread":0.2212029254864251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}