{"id":"W2343562979","doi":"10.1161/circresaha.115.307015","title":"Gene Therapy for Coagulation Disorders","year":2016,"lang":"en","type":"review","venue":"Circulation Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Clotting factor; Factor IX; Coagulation; Hemostasis; Medicine; Transgene; Gene; Vectors in gene therapy; Bioinformatics; Vector (molecular biology); Computational biology; Immunology; Biology; Intensive care medicine; Recombinant DNA; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002153427,0.0003308358,0.0005541063,0.0004464842,0.0003375772,0.0000947169,0.0005768707,0.0006074957,0.0001312643],"category_scores_gemma":[0.0002877368,0.0002613011,0.0005068581,0.0004309011,0.0002143165,0.000007397217,0.0001224303,0.0002829976,0.0001573902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001330003,"about_ca_system_score_gemma":0.0008239387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007591872,"about_ca_topic_score_gemma":0.00004392001,"domain_scores_codex":[0.9964422,0.000836238,0.0004630661,0.0008617314,0.0006923431,0.0007044202],"domain_scores_gemma":[0.9979501,0.0002585544,0.000149578,0.0009642166,0.0005242343,0.000153273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003015757,0.00005413959,0.0000180718,0.0006631172,0.0001646566,3.325404e-7,0.000007412119,0.00002061107,0.002509797,0.00003711707,0.001263037,0.9949601],"study_design_scores_gemma":[0.000751862,0.0009305578,0.00002088009,0.0005162171,0.00001612563,0.00000308918,0.000003270956,0.00003880115,0.0007412377,0.000433962,0.9962082,0.000335826],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006299337,0.9935008,0.001533779,0.000106101,0.0001383615,0.003480048,0.00013282,0.00002317653,0.0004550376],"genre_scores_gemma":[0.00199058,0.992582,0.00006483556,0.00002045855,0.0009389417,0.001457019,0.001700457,0.0001544877,0.001091251],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9949451,"threshold_uncertainty_score":0.9999839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1549179057864536,"score_gpt":0.4695268050582613,"score_spread":0.3146088992718077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}