{"id":"W2343681268","doi":"10.1038/onc.2016.116","title":"MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Cancer Institute; Celgene; Samuel Waxman Cancer Research Foundation; Foundation for the National Institutes of Health","keywords":"Biology; DNA damage; Histone; DNA repair; Homologous recombination; Chromatin; Molecular biology; DNA repair protein XRCC4; Cell biology; DNA; DNA methylation; Non-homologous end joining; Cancer research; Cell cycle; Cell; Gene expression; Gene; Nucleotide excision repair; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003299312,0.0001883081,0.0003147847,0.0002436797,0.00006309766,0.00001738846,0.0001635446,0.00006193053,0.000346203],"category_scores_gemma":[0.0003019111,0.0001322284,0.00007134099,0.0003927949,0.00003618393,0.0001262549,0.00006461632,0.00007133288,0.0008706105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003827548,"about_ca_system_score_gemma":0.0001223658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001586445,"about_ca_topic_score_gemma":0.001914263,"domain_scores_codex":[0.998206,0.00009894912,0.0002536817,0.0005092883,0.0003981901,0.000533866],"domain_scores_gemma":[0.9984995,0.00008367698,0.00003754135,0.0006058071,0.00007090535,0.0007025689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00190931,0.0004943476,0.05156516,0.00006008631,0.00009388029,0.0005466595,0.0004372277,7.185224e-7,0.8946155,0.00002393272,0.00205524,0.04819788],"study_design_scores_gemma":[0.00614372,0.001196033,0.2319823,0.0008975731,0.00004699708,0.00001616502,0.0001050675,0.00003399546,0.7007065,0.00006657511,0.0584233,0.0003817329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914827,0.0001331551,0.0001018178,0.001802603,0.00005074136,0.0007062858,0.00003232105,0.00009508022,0.005595245],"genre_scores_gemma":[0.9781019,0.00005401356,0.003638939,0.001214585,0.0001338801,0.0001164164,0.00001635591,0.0000383279,0.01668556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.193909,"threshold_uncertainty_score":0.9999073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04377347108432479,"score_gpt":0.3616950834584231,"score_spread":0.3179216123740983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}