{"id":"W2343690238","doi":"10.1038/srep24970","title":"Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Universitätsspital Zürich; Deutsche Forschungsgemeinschaft","keywords":"Mutant; Prion protein; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Cell biology; Chemistry; Biology; Disease; Signal transduction; Medicine; Biochemistry; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003227505,0.001161839,0.0003501289,0.0009186522,0.0003544524,0.0004655551,0.0005093834,0.0009521347,0.002145106],"category_scores_gemma":[0.0002182545,0.0005731983,0.0006666455,0.0002664268,0.0006905543,0.0004819519,0.0004781808,0.00127836,0.0009563066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006153956,"about_ca_system_score_gemma":0.0003180011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005357708,"about_ca_topic_score_gemma":0.0006840325,"domain_scores_codex":[0.9996507,0.00005863302,0.00004636224,0.00009047244,0.00007326109,0.00008049487],"domain_scores_gemma":[0.9995065,0.00006117987,0.0001965026,0.0000495894,0.00002723385,0.0001589982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002349386,0.0001242371,0.00021114,0.00003331278,0.00001422099,0.0003083537,0.00004638679,0.00007230455,0.9978335,0.0002624347,0.00007333624,0.0007857112],"study_design_scores_gemma":[0.0001770814,0.001154536,0.005440414,0.00003941518,0.0000525358,0.001667839,0.0000712468,0.002088586,0.9857438,0.0004612513,0.003084069,0.00001922559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910019,0.0009417991,0.004704677,0.0002866243,0.00005251388,0.00009364781,0.0008330381,0.0005909462,0.001494776],"genre_scores_gemma":[0.9861432,0.0009092424,0.004843682,0.0001305616,0.00003043251,0.0001741643,0.001236235,0.000138066,0.006394419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002145106,"threshold_uncertainty_score":0.007176101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132869162571257,"score_gpt":0.2290781650117823,"score_spread":0.2177494733860698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}