{"id":"W2343915366","doi":"10.1007/s00204-016-1720-0","title":"2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity","year":2016,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Terry Fox Research Institute; Ontario Institute for Cancer Research; Academy of Finland; Canadian Institutes of Health Research; Dow Chemical Company","keywords":"Toxicity; Abundance (ecology); RNA; Chemistry; Biology; Medicine; Internal medicine; Biochemistry; Ecology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009999485,0.0003145669,0.0001763258,0.0003668028,0.0001216937,0.0001862512,0.0001235042,0.0002120857,0.0007763766],"category_scores_gemma":[0.00009936731,0.0001177581,0.0002627606,0.000222791,0.0002329264,0.0001452671,0.0001656796,0.0002300658,0.0002489162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914687,"about_ca_system_score_gemma":0.0001328128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006024934,"about_ca_topic_score_gemma":0.001245287,"domain_scores_codex":[0.9998723,0.0000102743,0.000008873828,0.0000500077,0.00002572313,0.00003280292],"domain_scores_gemma":[0.9998796,0.00001392756,0.00005055567,0.000007486776,0.00001913942,0.00002921995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000102135,0.00000994949,0.003613447,0.0000300038,0.000004554813,0.00003998769,0.00001279169,0.00002144862,0.9953863,0.0000211366,0.00001917515,0.0007390851],"study_design_scores_gemma":[0.00001935068,0.0004075503,0.3573379,0.00001571707,0.00005719268,0.0004287164,0.0001894567,0.0008129427,0.6390012,0.00009438115,0.001623918,0.00001168521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954733,0.001411339,0.001401355,0.000066717,0.00001288977,0.00001638779,0.001016934,0.00003954775,0.0005613834],"genre_scores_gemma":[0.9919137,0.001175593,0.002423173,0.0001308912,0.00001016154,0.00004528803,0.001933613,0.00001719143,0.002350462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007763766,"threshold_uncertainty_score":0.002597272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05451493813368015,"score_gpt":0.3978568858871757,"score_spread":0.3433419477534956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}