{"id":"W2343968915","doi":"10.1021/acsami.6b00717","title":"Highly Hybridizable Spherical Nucleic Acids by Tandem Glutathione Treatment and Polythymine Spacing","year":2016,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cape Breton University","funders":"Beijing Higher Education Young Elite Teacher Project; Canadian Institutes of Health Research; China Scholarship Council; Ministry of Education of the People's Republic of China; Nova Scotia Health Research Foundation; Beatrice Hunter Cancer Research Institute","keywords":"DNA; Nucleic acid; Glutathione; Rational design; Combinatorial chemistry; Biophysics; Materials science; Nanobiotechnology; Poloxamer; Nanotechnology; Biochemistry; Nanoparticle; Chemistry; Biology; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183426,0.0004324057,0.0002146899,0.0001742796,0.00009826427,0.0002145735,0.0002950536,0.0003684885,0.0004536428],"category_scores_gemma":[0.0001749439,0.0002127972,0.0002361766,0.0001931701,0.0001891797,0.0002168112,0.0003143747,0.0002688635,0.0004037686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000217454,"about_ca_system_score_gemma":0.0001486022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003183444,"about_ca_topic_score_gemma":0.0008723343,"domain_scores_codex":[0.9998561,0.00001996876,0.00001319323,0.00004990817,0.00003802252,0.0000226773],"domain_scores_gemma":[0.9999027,0.00001558878,0.00003350839,0.00001269368,0.00002116465,0.00001425271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001094729,0.000003673991,0.00003702134,0.00001961546,0.000002518183,0.00001730272,0.00001014315,0.0001049554,0.9982095,0.00007198854,0.00001121381,0.00150118],"study_design_scores_gemma":[0.000002620217,0.00006713652,0.0001967941,9.791277e-7,0.000005179976,0.00004904034,0.000004369125,0.000838184,0.997759,0.00002160148,0.001051201,0.000003836091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579198,0.001459469,0.03788053,0.00007473966,0.00007247007,0.00007206009,0.0001196679,0.0004689211,0.001932266],"genre_scores_gemma":[0.9731752,0.0006053913,0.02348255,0.00004230826,0.000009614075,0.00005147872,0.00014693,0.00003924063,0.002447237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004536428,"threshold_uncertainty_score":0.001577735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006557353977657151,"score_gpt":0.2346692139147528,"score_spread":0.2281118599370957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}