{"id":"W2344029278","doi":"10.1039/9781849733151-00169","title":"Plasmodium falciparum Neutral Aminopeptidases: Development of Novel Anti-Malarials by Understanding Enzyme Structure","year":2011,"lang":"en","type":"book-chapter","venue":"","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Malaria; Aminopeptidase; Plasmodium falciparum; Plasmodium chabaudi; Parasite hosting; Biology; Drug development; Drug; Enzyme; Drug resistance; Malarial parasites; Plasmodium (life cycle); Biochemistry; Pharmacology; Immunology; Microbiology; Amino acid; Leucine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399556,0.0006327164,0.0003217389,0.000369864,0.0001923269,0.0009164551,0.0004155173,0.0005112696,0.01124748],"category_scores_gemma":[0.0001192422,0.0002116297,0.0001618747,0.0005385749,0.0003254315,0.001766449,0.0003896046,0.001216128,0.01216879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004812959,"about_ca_system_score_gemma":0.0003232617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002251092,"about_ca_topic_score_gemma":0.0006203608,"domain_scores_codex":[0.9999584,0.000004317449,0.000001987166,0.000009205947,0.00002216896,0.000003872074],"domain_scores_gemma":[0.9999751,0.000008038086,0.000003108368,0.000001952387,0.000006112289,0.000005803591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384067,0.00008241981,0.00007932573,0.00164453,0.00001067119,0.0001751249,0.0001985519,0.0009772023,0.02746508,0.05298297,0.1736685,0.7425772],"study_design_scores_gemma":[0.000009547947,0.00003457314,0.00009512252,0.000123672,0.000003722294,0.0002918607,0.00001650228,0.000260752,0.002417222,0.006433989,0.9903072,0.000005802522],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.005204207,0.6936308,0.02062187,0.006166785,0.003445408,0.0001115228,0.0004414309,0.0005650108,0.269813],"genre_scores_gemma":[0.01597817,0.5071964,0.03088808,0.002323077,0.001125661,0.0001079809,0.0006329008,0.0001549001,0.4415928],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01124748,"threshold_uncertainty_score":0.03762656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0795728336758164,"score_gpt":0.2684544367691223,"score_spread":0.1888816030933059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}