{"id":"W2344145345","doi":"10.1016/j.ymeth.2016.04.023","title":"Mutational analysis of FANCJ helicase","year":2016,"lang":"pl","type":"review","venue":"Methods","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Biology; Genetics; Helicase; Missense mutation; Fanconi anemia; Mutation; Genome instability; Gene; DNA repair; Cancer research; DNA; DNA damage; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002402066,0.0005310725,0.002061364,0.0004736099,0.00005594693,0.00001854916,0.0005423693,0.0007987425,0.001149359],"category_scores_gemma":[0.0008976001,0.0004134502,0.002220473,0.0009495453,0.0001495985,0.00000294579,0.0003156864,0.0001771969,0.00006335739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005098334,"about_ca_system_score_gemma":0.0004030855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000844193,"about_ca_topic_score_gemma":0.000004463593,"domain_scores_codex":[0.9951302,0.002147966,0.001081202,0.0009462218,0.0003075191,0.0003868728],"domain_scores_gemma":[0.997006,0.0003825666,0.0009090932,0.001225791,0.000300073,0.0001764584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002083864,0.00008749827,0.000007290118,0.001443301,0.007573029,0.00001309268,0.00001955275,0.000007036212,0.05377523,0.0004021495,0.0001446864,0.9365063],"study_design_scores_gemma":[0.0002344907,0.0001954653,0.00001922807,0.0007448245,0.01003322,0.00003183446,0.000009134983,0.00010877,0.07197232,0.0001873568,0.9159345,0.000528876],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001834535,0.6939973,0.3031129,0.00002463149,0.0003980088,0.0003463524,0.0006964469,0.00001101371,0.001229921],"genre_scores_gemma":[0.0001129639,0.7076236,0.2860951,0.00008393644,0.0002863846,0.00009529775,0.001098649,0.00006872089,0.004535416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9359774,"threshold_uncertainty_score":0.9998317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04956062745938734,"score_gpt":0.4501775206021925,"score_spread":0.4006168931428052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}