{"id":"W2344220366","doi":"10.1021/acs.molpharmaceut.6b00075","title":"ChAcNLS, a Novel Modification to Antibody-Conjugates Permitting Target Cell-Specific Endosomal Escape, Localization to the Nucleus, and Enhanced Total Intracellular Accumulation","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Banting Research Foundation; Faculté de médecine et des sciences de la santé, Université de Sherbrooke; Cancer Research Society","keywords":"Intracellular; Endosome; Cell biology; Nuclear transport; Flow cytometry; Chemistry; Cell; Biophysics; Biochemistry; Molecular biology; Biology; Cell nucleus; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003246156,0.0002386901,0.000227977,0.0001487541,0.0002313377,0.0000732713,0.0001579044,0.0000901211,0.00009968885],"category_scores_gemma":[0.0001028481,0.0001580456,0.00007581216,0.000358557,0.00007723421,0.0001031465,0.0001622601,0.0001852749,0.0001500956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007228296,"about_ca_system_score_gemma":0.00005136382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001728084,"about_ca_topic_score_gemma":8.310222e-7,"domain_scores_codex":[0.998129,0.00008516679,0.000348052,0.0004661822,0.0005222298,0.0004493422],"domain_scores_gemma":[0.9989231,0.00009796781,0.00007866759,0.000306317,0.0002417879,0.0003521274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003088783,0.0001255621,0.0008159951,0.00006610824,0.00003872082,0.00002026693,0.0005801735,0.001152598,0.9822963,0.0006691232,0.0002613635,0.01366487],"study_design_scores_gemma":[0.001183471,0.0001592949,0.002168674,0.00009218213,0.00004452174,0.00004144674,0.00009172163,0.03058844,0.9070076,0.00003457894,0.0583577,0.0002303363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.692609,0.0008202,0.2981035,0.007072173,0.0001114738,0.0008672411,0.00004402292,0.00004544152,0.0003270106],"genre_scores_gemma":[0.9924241,0.0003754895,0.004605279,0.001436335,0.0002680051,0.00004332081,0.00008767555,0.00004813714,0.0007116523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2998151,"threshold_uncertainty_score":0.6444914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05122800022407144,"score_gpt":0.3633113097127117,"score_spread":0.3120833094886403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}