{"id":"W2344220366","doi":"10.1021/acs.molpharmaceut.6b00075","title":"ChAcNLS, a Novel Modification to Antibody-Conjugates Permitting Target Cell-Specific Endosomal Escape, Localization to the Nucleus, and Enhanced Total Intracellular Accumulation","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Banting Research Foundation; Faculté de médecine et des sciences de la santé, Université de Sherbrooke; Cancer Research Society","keywords":"Intracellular; Endosome; Cell biology; Nuclear transport; Flow cytometry; Chemistry; Cell; Biophysics; Biochemistry; Molecular biology; Biology; Cell nucleus; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000178097,0.0004354911,0.0002113456,0.0002644428,0.0001525221,0.0002090417,0.0002692095,0.0003858713,0.0005780187],"category_scores_gemma":[0.0001430761,0.0001625246,0.0002464842,0.0002114515,0.0002816119,0.0002581447,0.0001903084,0.000314563,0.000253567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005854585,"about_ca_system_score_gemma":0.0003939958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025078,"about_ca_topic_score_gemma":0.001267135,"domain_scores_codex":[0.9998862,0.00002201052,0.0000096225,0.00003095152,0.00003216957,0.00001897442],"domain_scores_gemma":[0.9999275,0.00001073624,0.00002470188,0.000006075433,0.00001810442,0.0000129279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003977512,0.00000800313,0.00004897432,0.00004720427,0.000003869751,0.00003387015,0.000005668638,0.00007348959,0.9981116,0.0001232311,0.00004235324,0.001462018],"study_design_scores_gemma":[0.00001381306,0.0001689156,0.000555428,0.000003182691,0.000009651482,0.0002607505,0.000003505236,0.0005473538,0.9946604,0.00002230308,0.003748992,0.000005797103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9349936,0.007272107,0.04986322,0.0003239868,0.0001313852,0.000252388,0.0004166033,0.0004111941,0.006335623],"genre_scores_gemma":[0.9684563,0.00310187,0.0198735,0.000269272,0.00004063763,0.000151513,0.0006630218,0.00005165601,0.007392217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001025078,"threshold_uncertainty_score":0.004247785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05122800022407144,"score_gpt":0.3633113097127117,"score_spread":0.3120833094886403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}