{"id":"W2344240677","doi":"10.1111/tpj.13186","title":"<i>Rauvolfia serpentina N‐</i>methyltransferases involved in ajmaline and <i>N</i><sub>β</sub>‐methylajmaline biosynthesis belong to a gene family derived from γ‐tocopherol <i>C</i>‐methyltransferase","year":2016,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología; Canada Foundation for Innovation; Genome British Columbia; Genome Prairie; National Research Council Canada; Genome Canada; Genome Alberta; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; McGill University","keywords":"Ajmaline; Methyltransferase; Biosynthesis; Gene; Gene family; Tocopherol; Genetics; Biology; Chemistry; Stereochemistry; Biochemistry; Methylation; Gene expression; Neuroscience; Vitamin E","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001043075,0.0005206985,0.0005135188,0.0001305417,0.0002828779,0.0001064979,0.0006252099,0.0003075652,0.00002922],"category_scores_gemma":[0.0003190183,0.0003192762,0.000205458,0.000238937,0.0001935462,0.00002527281,0.0001384411,0.000326521,0.00001921565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003621311,"about_ca_system_score_gemma":0.0001377465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007664414,"about_ca_topic_score_gemma":0.0004220437,"domain_scores_codex":[0.9970879,0.0004311507,0.0007104711,0.0006975036,0.0003646718,0.0007082897],"domain_scores_gemma":[0.9983554,0.0004705391,0.0001502843,0.0004969503,0.00009885737,0.0004279517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001752813,0.0001391938,0.003062295,0.00001592898,0.0001907953,0.0001234238,0.00009090701,0.00001140761,0.9879031,0.00000159585,0.0005222477,0.006186339],"study_design_scores_gemma":[0.001566535,0.000221073,0.01046765,0.0002703423,0.0001100823,0.0002201135,0.0001153954,0.00001047233,0.9847684,0.00006630811,0.001654716,0.000528911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902068,0.001949399,0.002592983,0.002659589,0.0001705545,0.0004224003,0.001943064,0.00002669621,0.00002853257],"genre_scores_gemma":[0.991237,0.005491566,0.0009078826,0.001583645,0.0005232095,0.00004234157,0.0001415368,0.0000509894,0.00002185388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007405356,"threshold_uncertainty_score":0.9999259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314460194170607,"score_gpt":0.2047257084937559,"score_spread":0.1915811065520498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}