{"id":"W2344273352","doi":"10.1093/eurheartj/ehw148","title":"Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol","year":2016,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":682,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"St. Jude Medical; Servier; Merck Sharp and Dohme; Sydäntutkimussäätiö; Schweizerische Herzstiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Foundation; Boston Scientific Corporation; Helsingin ja Uudenmaan Sairaanhoitopiiri; Zora Biosciences; Danone; Foundation for Cardiovascular Research; Daiichi Sankyo Europe; Sanofi; European Commission; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Cardiology; Internal medicine; Coronary artery disease; Cholesterol; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008090467,0.0005935692,0.0003456364,0.0006023099,0.0002878373,0.0006133272,0.0002732349,0.00070234,0.00107301],"category_scores_gemma":[0.00188406,0.0001978893,0.0004528651,0.0003255469,0.0002417488,0.0003085754,0.0004643053,0.0005818221,0.0002105078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000187683,"about_ca_system_score_gemma":0.0002885707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001549954,"about_ca_topic_score_gemma":0.001928231,"domain_scores_codex":[0.9998227,0.00005618094,0.00001928597,0.00004417307,0.00002608138,0.00003158084],"domain_scores_gemma":[0.999306,0.0001646625,0.0002244427,0.00005514629,0.00007556966,0.0001742867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007770954,0.00002930201,0.9975755,0.00001052026,0.00006713243,0.0000506834,0.00002214225,0.00005098849,0.0004022959,0.000007936871,0.00003837663,0.0009680521],"study_design_scores_gemma":[0.00006113668,0.0002397287,0.9984731,0.000009010756,0.0001242748,0.0002266651,0.00009442179,0.0004540513,0.0001708558,0.00005605895,0.00008583897,0.000004882105],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992478,0.0004182421,0.00005403466,0.0000293792,0.000006444958,0.000004725324,0.0001096922,0.000002106117,0.0001276362],"genre_scores_gemma":[0.9995188,0.00008189528,0.00008391656,0.00001278909,0.00001136615,0.000003630019,0.0002079997,6.189601e-7,0.0000791653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549954,"threshold_uncertainty_score":0.00427866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124514266376852,"score_gpt":0.2092078040394268,"score_spread":0.1979626613756583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}