{"id":"W2344314327","doi":"10.1371/journal.pone.0154255","title":"Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Mitsui Sumitomo Insurance Welfare Foundation; Japan Society for the Promotion of Science; Nakatomi Foundation; Eisai Canada; Astellas Foundation for Research on Metabolic Disorders; Japan Research Foundation for Clinical Pharmacology; Abbott Japan; Daiwa Securities Health Foundation; Takeda Science Foundation; Astellas Pharma; Astellas Pharma US","keywords":"Allele; Immunology; Multiple sclerosis; Human leukocyte antigen; Medicine; Antigen; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007694548,0.0003291068,0.000759945,0.0001575826,0.0002673465,0.0000444651,0.0002991713,0.0002936881,0.00005003716],"category_scores_gemma":[0.0003741201,0.0001591641,0.0001300183,0.0003088764,0.0003995627,0.0001179376,0.0002237393,0.0003541516,0.0000202537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681103,"about_ca_system_score_gemma":0.0001288098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006298516,"about_ca_topic_score_gemma":0.0001576224,"domain_scores_codex":[0.9970905,0.0003913667,0.0007001158,0.0005541232,0.0008449019,0.0004189903],"domain_scores_gemma":[0.9982312,0.0002824674,0.0003979579,0.0007137497,0.0001818428,0.0001927915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002618406,0.0008758185,0.1628885,0.0008122243,0.0009273266,0.00001437062,0.002967281,0.000002448179,0.8298411,0.00007760034,0.0003268908,0.00100462],"study_design_scores_gemma":[0.00629787,0.0004320398,0.9035345,0.02473024,0.0007124185,0.00009118321,0.003292486,0.00005434201,0.06034806,0.0001357966,0.00001248361,0.0003585856],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870417,0.008480315,0.000004357564,0.001154389,0.00005534875,0.002839547,0.00003177984,0.00005399022,0.0003386218],"genre_scores_gemma":[0.9963995,0.00215488,0.00001418265,0.0001313833,0.0001545192,0.0002628148,0.000003352234,0.00005353215,0.0008258837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7694931,"threshold_uncertainty_score":0.6490522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0584812094773178,"score_gpt":0.2286235204914315,"score_spread":0.1701423110141137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}