{"id":"W2344314327","doi":"10.1371/journal.pone.0154255","title":"Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Mitsui Sumitomo Insurance Welfare Foundation; Japan Society for the Promotion of Science; Nakatomi Foundation; Eisai Canada; Astellas Foundation for Research on Metabolic Disorders; Japan Research Foundation for Clinical Pharmacology; Abbott Japan; Daiwa Securities Health Foundation; Takeda Science Foundation; Astellas Pharma; Astellas Pharma US","keywords":"Allele; Immunology; Multiple sclerosis; Human leukocyte antigen; Medicine; Antigen; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003921395,0.0002651962,0.0002462652,0.0003413041,0.0003501943,0.0003019797,0.0001470782,0.0003479347,0.001566757],"category_scores_gemma":[0.0007517199,0.0002093119,0.0002400887,0.0007870605,0.0003094896,0.0001825141,0.0002393409,0.0003389924,0.0001073992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718153,"about_ca_system_score_gemma":0.0002599514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01182055,"about_ca_topic_score_gemma":0.01092567,"domain_scores_codex":[0.9997867,0.00005612756,0.00002088844,0.00007327293,0.00003339858,0.00002965767],"domain_scores_gemma":[0.9995236,0.00007838783,0.0001870648,0.0000318828,0.00005318553,0.0001259063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001654869,0.0000184135,0.995011,0.0000347003,0.00009216538,0.000230084,0.0001982476,0.00002612892,0.00143073,0.00001886243,0.00009518974,0.002679006],"study_design_scores_gemma":[0.00001001277,0.00005690564,0.9988386,0.000008049029,0.00006627302,0.0005769279,0.0001285847,0.0000595061,0.00004831066,0.00002076447,0.0001840645,0.000001981593],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988355,0.0008503928,0.00004336594,0.00006315871,0.00000528149,0.000002002589,0.00003301665,0.000001322266,0.0001660567],"genre_scores_gemma":[0.9994081,0.0003143273,0.00005088117,0.00003102701,0.00001024515,0.00000203204,0.00004326696,7.56171e-7,0.0001394127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01182055,"threshold_uncertainty_score":0.02350348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0584812094773178,"score_gpt":0.2286235204914315,"score_spread":0.1701423110141137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}