{"id":"W2344331730","doi":"10.1038/nchembio.2069","title":"A small molecule mitigates hearing loss in a mouse model of Usher syndrome III","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Institute on Deafness and Other Communication Disorders; National Eye Institute","keywords":"Usher syndrome; Hearing loss; Small molecule; Mutation; Medicine; Gene; Biology; Audiology; Retinitis pigmentosa; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008668578,0.0001399069,0.000211952,0.00003545023,0.000009929508,0.000001909448,0.0001738858,0.0008032499,0.00001608034],"category_scores_gemma":[0.00004673073,0.0001020501,0.0001019882,0.00005787434,0.0001507298,0.000002163539,0.00006085586,0.0001980545,0.000002168264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001596963,"about_ca_system_score_gemma":0.000034705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001205323,"about_ca_topic_score_gemma":0.00002023813,"domain_scores_codex":[0.9991181,0.00002024056,0.0002226345,0.0003456883,0.00004732135,0.0002459957],"domain_scores_gemma":[0.9996094,0.00001374997,0.00005124795,0.0002187279,0.00004684068,0.0000600736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000131591,0.00005093419,0.007267616,0.00001548599,0.00002066196,0.000004699275,0.00001515361,0.000004657494,0.9920203,0.0002916956,0.000007179785,0.0001700291],"study_design_scores_gemma":[0.0008515975,0.00007116761,0.0001911966,0.00002179013,0.000006524919,0.00001370664,0.000003330229,0.00009385403,0.9978085,0.0004823291,0.00030836,0.0001476104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951331,0.0006271173,0.003707201,0.0001605985,0.00003481176,0.00009570608,0.00003838132,0.00001002921,0.0001930377],"genre_scores_gemma":[0.9984186,0.00009977842,0.0005844885,0.0001422933,0.00003359145,0.00001145523,0.0004527461,0.00001571585,0.0002413905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007076419,"threshold_uncertainty_score":0.6195399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00995229776575936,"score_gpt":0.2210788382139713,"score_spread":0.2111265404482119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}