{"id":"W2344414687","doi":"10.1074/jbc.m115.709659","title":"Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Else Kröner-Fresenius-Stiftung; European Social Fund; Deutsche Forschungsgemeinschaft","keywords":"Extracellular; Chemistry; Receptor; Biophysics; G protein-coupled receptor; Transmembrane domain; Homology modeling; Ligand (biochemistry); Docking (animal); Cell biology; Biochemistry; Biology; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558743,0.0002874281,0.0002922035,0.00009525901,0.0002972029,0.0004238522,0.0003006791,0.0003322664,0.001405387],"category_scores_gemma":[0.0003707418,0.0001781488,0.0003018979,0.0001223621,0.0002396265,0.0003834853,0.0003283851,0.0006755524,0.0004938095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004170078,"about_ca_system_score_gemma":0.0003758454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008121781,"about_ca_topic_score_gemma":0.0008128665,"domain_scores_codex":[0.9998589,0.00001962416,0.00001098682,0.00003509325,0.0000492238,0.00002615511],"domain_scores_gemma":[0.9998459,0.00003981631,0.00005726013,0.00001056665,0.00001737836,0.00002905796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004118117,0.0000725352,0.003274915,0.0001110064,0.00001746179,0.0006177663,0.00009114826,0.005138962,0.9844179,0.0009672416,0.0002787552,0.004600524],"study_design_scores_gemma":[0.0001922011,0.0004985034,0.04257486,0.00005458332,0.00008161648,0.00200388,0.0003439664,0.0674156,0.876303,0.002193767,0.008255831,0.00008226531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910104,0.0006505582,0.006237142,0.0001560994,0.0000293103,0.00002461696,0.0002395599,0.0001504174,0.001501935],"genre_scores_gemma":[0.9965097,0.0002219751,0.002539325,0.00006292968,0.0000047081,0.00001398957,0.0003304825,0.00001937665,0.0002974364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405387,"threshold_uncertainty_score":0.004701495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330442095577938,"score_gpt":0.2702991849332481,"score_spread":0.2469947639774687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}