{"id":"W2344498508","doi":"10.1371/journal.pone.0153564","title":"A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Deutsche Parkinson Vereinigung; Bayer HealthCare; Alberta Prion Research Institute; Ottawa Hospital Research Institute; Stifterverband; Bundesministerium für Bildung und Forschung; Biogen; GlaxoSmithKline; Teva Pharmaceutical Industries; Eli Lilly and Company; Michael J. Fox Foundation for Parkinson's Research","keywords":"Cerebrospinal fluid; Multiplex; Biomarker; Reproducibility; Detection limit; Immunoassay; Analyte; Chromatography; Medicine; Chemistry; Pathology; Biology; Bioinformatics; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006901313,0.0008648245,0.0005695891,0.0005295683,0.0002281151,0.0006336935,0.0006275418,0.001494999,0.0009168538],"category_scores_gemma":[0.001449908,0.0002832548,0.0003526836,0.0003106697,0.0004028313,0.0007034728,0.0004236424,0.0009145038,0.0004861022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004223689,"about_ca_system_score_gemma":0.0002832921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001513398,"about_ca_topic_score_gemma":0.0002462251,"domain_scores_codex":[0.9991475,0.0001391315,0.00006557413,0.0003866025,0.000195634,0.00006549482],"domain_scores_gemma":[0.999351,0.0002662863,0.000149436,0.00005286739,0.0001095585,0.00007086046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006211272,0.00005766211,0.0002047564,0.00006892859,0.00001531388,0.00006193799,0.00004807674,0.0001496665,0.9918517,0.00009309837,0.0001625398,0.007224174],"study_design_scores_gemma":[0.00001247945,0.0008608664,0.001223063,0.00001115364,0.00001914766,0.0005056303,0.00001930987,0.002873223,0.991827,0.0001375431,0.002491576,0.00001888823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.644006,0.004779733,0.343931,0.0006338719,0.0003160121,0.0007731569,0.001868851,0.001581706,0.002109691],"genre_scores_gemma":[0.7731846,0.001854269,0.2159488,0.0006376959,0.0001121569,0.0007073557,0.002006704,0.00008702279,0.005461412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494999,"threshold_uncertainty_score":0.003649831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04382607672001423,"score_gpt":0.2646118319197188,"score_spread":0.2207857551997045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}