{"id":"W2344572401","doi":"10.1038/srep25082","title":"Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Department of Medicine, University of California, San Francisco; Chi Mei Medical Center; Ministry of Science and Technology, Taiwan; University of California, San Francisco; Howard Hughes Medical Institute","keywords":"Lovastatin; Survivin; AMPK; Protein kinase A; Cancer research; Apoptosis; Chemistry; Programmed cell death; Cell biology; Biology; Kinase; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008257955,0.0002526279,0.0002569678,0.000111729,0.0002546776,0.0001269971,0.0002044545,0.0001404593,0.000134554],"category_scores_gemma":[0.0001142974,0.0001923388,0.000189841,0.0001811553,0.000187883,0.00001852184,0.0001544328,0.00007778728,0.0000441524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003394592,"about_ca_system_score_gemma":0.0003206042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002113835,"about_ca_topic_score_gemma":0.0002240342,"domain_scores_codex":[0.9973907,0.00006773287,0.0005013394,0.001084231,0.0004131203,0.0005428242],"domain_scores_gemma":[0.9983168,0.00001884008,0.0002953594,0.0009647854,0.0002041905,0.0002000815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002124395,0.00004670991,0.008718516,0.00002014696,0.00001590799,0.00001083722,0.00007237183,0.0000102489,0.937488,0.00001060818,0.05149608,0.002089347],"study_design_scores_gemma":[0.0002548677,0.00003354582,0.001886059,0.00001418504,0.00002333426,0.0001502994,0.00003199696,0.000004641294,0.593475,0.0002508442,0.4036414,0.0002338033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619724,0.001725514,0.002157368,0.00008038641,0.03254813,0.0002513327,0.00002849391,0.00003273872,0.001203658],"genre_scores_gemma":[0.9781421,0.00005456516,0.0005646379,0.00008541555,0.004867439,0.00002647926,0.00009993555,0.00004038097,0.01611899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3521453,"threshold_uncertainty_score":0.7843348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319592783942029,"score_gpt":0.2369821741463251,"score_spread":0.2237862463069048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}