{"id":"W2344572401","doi":"10.1038/srep25082","title":"Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Department of Medicine, University of California, San Francisco; Chi Mei Medical Center; Ministry of Science and Technology, Taiwan; University of California, San Francisco; Howard Hughes Medical Institute","keywords":"Lovastatin; Survivin; AMPK; Protein kinase A; Cancer research; Apoptosis; Chemistry; Programmed cell death; Cell biology; Biology; Kinase; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007804923,0.0002954299,0.0003240491,0.0002421687,0.0002447564,0.0001888686,0.0001182585,0.0002210628,0.0008179016],"category_scores_gemma":[0.00006459258,0.0001016216,0.0003271049,0.0001564884,0.0001418098,0.0001480187,0.0001336287,0.0004083093,0.0002155429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003845294,"about_ca_system_score_gemma":0.0002332919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001459437,"about_ca_topic_score_gemma":0.00230228,"domain_scores_codex":[0.9998924,0.00001801959,0.00001236742,0.00001725295,0.00001958275,0.00004038011],"domain_scores_gemma":[0.9999763,0.000002724617,0.000006553136,0.000003921334,0.000003794878,0.000006696305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006339586,0.00009523319,0.000862633,0.0001227203,0.00002252267,0.000300859,0.00003006885,0.00005893514,0.9931523,0.0001644197,0.0002098386,0.004346455],"study_design_scores_gemma":[0.00008966055,0.001033901,0.01355802,0.00001196839,0.00005457421,0.0008775714,0.0000841119,0.0008890369,0.9759964,0.0001344654,0.007261612,0.000008671989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856032,0.009601758,0.001808541,0.0002871094,0.00009672682,0.00004293553,0.0004033472,0.0001044862,0.002051936],"genre_scores_gemma":[0.9957759,0.001961051,0.0005340403,0.00008224035,0.00001259049,0.00003571419,0.0002976962,0.00000484582,0.001295948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459437,"threshold_uncertainty_score":0.002901852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319592783942029,"score_gpt":0.2369821741463251,"score_spread":0.2237862463069048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}