{"id":"W2344579973","doi":"10.1182/blood-2016-01-688226","title":"Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Adenosine deaminase deficiency; Severe combined immunodeficiency; Genetic enhancement; Adenosine deaminase; Medicine; Adverse effect; Immunology; Internal medicine; Oncology; Virology; Gene; Biology; Adenosine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005164423,0.0005480892,0.001640304,0.0009478926,0.0003153142,0.001803068,0.001379199,0.002357729,0.001672828],"category_scores_gemma":[0.006690629,0.000274657,0.000896912,0.001250359,0.0006089859,0.001478858,0.0004244777,0.003431909,0.001000985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008561507,"about_ca_system_score_gemma":0.0009426344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009803,"about_ca_topic_score_gemma":0.001828487,"domain_scores_codex":[0.998333,0.0004304237,0.0004215277,0.0001303749,0.0006107219,0.00007386885],"domain_scores_gemma":[0.9888544,0.006256544,0.001221052,0.0002030615,0.003162642,0.0003023736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001060201,0.0001820562,0.001194831,0.004963985,0.0003177368,0.0003701827,0.0001267821,0.0005394894,0.005897062,0.001473149,0.03720202,0.9466725],"study_design_scores_gemma":[0.0002717489,0.003246827,0.006781049,0.004093118,0.001086021,0.001883497,0.0001569177,0.0005847851,0.005846064,0.001364731,0.9746253,0.00005981241],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.009512416,0.9607324,0.002411174,0.01286171,0.002374275,0.00005354777,0.0003472798,0.000137128,0.01157005],"genre_scores_gemma":[0.06113469,0.9006108,0.004873494,0.01822218,0.008927448,0.0001343271,0.001170673,0.0001086185,0.004817678],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005164423,"threshold_uncertainty_score":0.02731246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359156115148987,"score_gpt":0.2708198847432863,"score_spread":0.2572283235917965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}