{"id":"W2344579973","doi":"10.1182/blood-2016-01-688226","title":"Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Adenosine deaminase deficiency; Severe combined immunodeficiency; Genetic enhancement; Adenosine deaminase; Medicine; Adverse effect; Immunology; Internal medicine; Oncology; Virology; Gene; Biology; Adenosine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004647924,0.0001436139,0.0001462201,0.00004810298,0.0001234039,0.00001296969,0.0003236295,0.00007419866,0.00002214285],"category_scores_gemma":[0.0001737976,0.00008042137,0.00007797145,0.0001152561,0.0001243508,0.000002602481,0.0000858092,0.00004538564,0.000008979575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007769719,"about_ca_system_score_gemma":0.00006946253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004962075,"about_ca_topic_score_gemma":0.000005434697,"domain_scores_codex":[0.9989113,0.0000836726,0.0002020975,0.00033812,0.0001647664,0.0003000028],"domain_scores_gemma":[0.9991446,0.00008699417,0.00006077325,0.0005533395,0.0000939707,0.00006029196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004235657,0.0003489892,0.0002148125,0.000004790765,0.00003494822,0.000001255353,0.0000300388,0.000004137651,0.9739802,0.0002135049,0.0001146792,0.02081703],"study_design_scores_gemma":[0.003451098,0.007658725,0.003782711,0.00001339519,0.00001159087,0.000008375112,0.00001079587,0.000002061102,0.9824646,0.00005677019,0.002409624,0.000130318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944054,0.002575703,0.0009610849,0.001224571,0.00003113388,0.0005849028,0.0001032835,0.000007321227,0.0001065371],"genre_scores_gemma":[0.9980721,0.0009683684,0.0002253344,0.0004276211,0.00007169769,0.00004232741,0.00001545394,0.00002568906,0.0001513958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02068671,"threshold_uncertainty_score":0.3279488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359156115148987,"score_gpt":0.2708198847432863,"score_spread":0.2572283235917965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}