{"id":"W2344586567","doi":"10.1021/acs.jmedchem.5b01997","title":"Identification and Development of 2,3-Dihydropyrrolo[1,2-<i>a</i>]quinazolin-5(1<i>H</i>)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; Engineering and Physical Sciences Research Council; Healthway; Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Bromodomain; Chemistry; SMARCA4; Binding site; Acetylation; Computational biology; Chromatin; Biochemistry; Stereochemistry; Biophysics; Chromatin remodeling; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001318158,0.0001509625,0.0002235329,0.00003350171,0.0001393365,0.00001828949,0.0002433783,0.0001127836,0.00002730245],"category_scores_gemma":[0.0004681392,0.0000913167,0.00007091062,0.0000722245,0.0002274805,0.00001583334,0.0001051486,0.0001561335,0.000001264886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003439696,"about_ca_system_score_gemma":0.0002190011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001437924,"about_ca_topic_score_gemma":0.000001351258,"domain_scores_codex":[0.9982184,0.00004997327,0.0009431322,0.0001844117,0.0004298281,0.0001742957],"domain_scores_gemma":[0.9983023,0.00003676857,0.001086285,0.0001816061,0.0002744482,0.0001185931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031453,0.00006033698,0.001230972,0.00007374447,0.00006305869,0.000002601136,0.0002179786,0.000002584345,0.9943114,0.000005422925,0.0006793739,0.003249401],"study_design_scores_gemma":[0.0009871661,0.00008389686,0.001253846,0.0002252106,0.00002790892,0.0000937633,0.0004888937,0.00001412588,0.9925352,0.00004541093,0.004127165,0.0001174564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993877,0.0006717916,0.0042935,0.0007971407,0.0001391651,0.0000886507,0.000003840786,0.000004264791,0.0001246584],"genre_scores_gemma":[0.9972655,0.00009860159,0.001815414,0.00008626236,0.0005567126,0.000003777274,0.00001094679,0.00001511164,0.0001476754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003447791,"threshold_uncertainty_score":0.3723787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492811958943573,"score_gpt":0.2473332073935572,"score_spread":0.2324050878041215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}