{"id":"W2344586567","doi":"10.1021/acs.jmedchem.5b01997","title":"Identification and Development of 2,3-Dihydropyrrolo[1,2-<i>a</i>]quinazolin-5(1<i>H</i>)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; Engineering and Physical Sciences Research Council; Healthway; Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Bromodomain; Chemistry; SMARCA4; Binding site; Acetylation; Computational biology; Chromatin; Biochemistry; Stereochemistry; Biophysics; Chromatin remodeling; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002891884,0.0005161357,0.0005063108,0.0003397617,0.0001368143,0.0003375447,0.0004628294,0.0003135489,0.0009045735],"category_scores_gemma":[0.0001779469,0.0001868004,0.0003048934,0.0001636169,0.0002426371,0.000240018,0.0001802771,0.0005430267,0.0003249866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004528877,"about_ca_system_score_gemma":0.000417318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006437991,"about_ca_topic_score_gemma":0.001489855,"domain_scores_codex":[0.9999013,0.00001975889,0.000006968844,0.00002117282,0.00002295506,0.00002782735],"domain_scores_gemma":[0.9999069,0.00001327944,0.00002591339,0.000007790248,0.00002100052,0.00002513457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004709991,0.0002837944,0.0005956015,0.0002570063,0.00003834226,0.0002546381,0.0000562141,0.001471943,0.9723828,0.0008741851,0.0004971005,0.02281741],"study_design_scores_gemma":[0.00110782,0.005382398,0.006770372,0.00003718437,0.000154189,0.001941582,0.00003452524,0.004800801,0.9576592,0.0002866131,0.02176808,0.00005722317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9266556,0.0265107,0.03707527,0.0006701974,0.0001306326,0.0008481903,0.001238751,0.0005333287,0.006337355],"genre_scores_gemma":[0.9716367,0.008177862,0.01486434,0.0001937663,0.00003427198,0.000226912,0.001657916,0.00002698585,0.003181186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009045735,"threshold_uncertainty_score":0.003285944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492811958943573,"score_gpt":0.2473332073935572,"score_spread":0.2324050878041215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}