{"id":"W2344653911","doi":"10.1371/journal.pone.0153823","title":"Toll-Like Receptor 1/2 and 5 Ligands Enhance the Expression of Cyclin D1 and D3 and Induce Proliferation in Mantle Cell Lymphoma","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Fondazione Italiana per la Ricerca sul Cancro; Associazione Italiana per la Ricerca sul Cancro; Fondazione Umberto Veronesi","keywords":"Cyclin D1; TLR5; TLR2; Mantle cell lymphoma; Cell biology; Cell growth; Cyclin D3; Cancer research; Biology; Toll-like receptor; Cell culture; Protein kinase B; CD40; Cyclin D; CD5; Signal transduction; Receptor; Cell cycle; Lymphoma; Cell; Immunology; Cytotoxic T cell; TLR4; Genetics; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004702125,0.0001603427,0.0001342449,0.0002472414,0.00008719489,0.0001698661,0.00006371389,0.0001168158,0.002314674],"category_scores_gemma":[0.00006155139,0.00007798309,0.0001941869,0.00009628927,0.00009482678,0.00009047913,0.000128452,0.0002567894,0.0003256776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686746,"about_ca_system_score_gemma":0.0001121402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004304832,"about_ca_topic_score_gemma":0.0007461876,"domain_scores_codex":[0.9999467,0.00001025367,0.000003828513,0.000007629114,0.00001069162,0.00002086349],"domain_scores_gemma":[0.9999678,0.000005977994,0.000005594023,0.000003408575,0.000003986732,0.00001327731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003020743,0.00008416016,0.0005571363,0.00007633891,0.000006442211,0.0000881816,0.00002252781,0.00004534925,0.9962903,0.00006621164,0.0001413642,0.002319917],"study_design_scores_gemma":[0.00009275346,0.001344744,0.02406882,0.00001584269,0.00002973061,0.0004734694,0.000120734,0.0005219296,0.9605091,0.0001110971,0.01270622,0.000005608679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909305,0.004851171,0.0007911487,0.00009957389,0.00004670558,0.00002354467,0.0004165887,0.00007031286,0.002770444],"genre_scores_gemma":[0.9943891,0.00131088,0.0004978611,0.00006700083,0.00001272684,0.00002221083,0.0003665834,0.000007287976,0.003326421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002314674,"threshold_uncertainty_score":0.007743418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972616698334747,"score_gpt":0.2308271109622446,"score_spread":0.2111009439788971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}