{"id":"W2344819016","doi":"10.1038/npp.2016.60","title":"Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype","year":2016,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"inVentiv Health Clinical","funders":"National Institute for Health and Care Research; GlaxoSmithKline","keywords":"Naltrexone; Opioid; Opioid receptor; Single-nucleotide polymorphism; Internal medicine; Pharmacogenetics; Alcohol dependence; Genotype; Opioid antagonist; Placebo; Pharmacology; Medicine; Endocrinology; Psychology; Chemistry; Receptor; Alcohol; Genetics; Biology; Gene; (+)-Naloxone; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004713869,0.0004251299,0.0009509392,0.0002950601,0.0002406796,0.0003545296,0.0002048898,0.0006111175,0.001161061],"category_scores_gemma":[0.0008341002,0.000358559,0.000599956,0.0002283869,0.000320509,0.000218047,0.0002863964,0.0004019837,0.0001859474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846812,"about_ca_system_score_gemma":0.0001712984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132724,"about_ca_topic_score_gemma":0.002044705,"domain_scores_codex":[0.9996147,0.0001400393,0.00004246867,0.00008553272,0.00005041259,0.0000668803],"domain_scores_gemma":[0.9993795,0.0001528745,0.0002128115,0.00006477744,0.00002491054,0.0001651409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3303258,0.008017404,0.5297365,0.0001354252,0.001733205,0.0006426104,0.0003729164,0.0005056979,0.1062613,0.00004704756,0.0002683313,0.02195379],"study_design_scores_gemma":[0.002820306,0.01874896,0.9748499,0.000006074778,0.0005371419,0.0002301115,0.00009003565,0.0005708699,0.001916431,0.00004380548,0.0001659593,0.00002029823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998411,0.00007312412,0.00001563829,0.00000659376,0.000002021418,0.000006592238,0.00002484572,0.000001206485,0.00002884035],"genre_scores_gemma":[0.9996426,0.00005156137,0.00007038235,0.00002456314,0.000006771067,0.0000122364,0.00008356213,0.000001470789,0.0001068181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161061,"threshold_uncertainty_score":0.003884137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007273564077567339,"score_gpt":0.2719908045216537,"score_spread":0.2647172404440863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}