{"id":"W2344819016","doi":"10.1038/npp.2016.60","title":"Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype","year":2016,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"inVentiv Health Clinical","funders":"National Institute for Health and Care Research; GlaxoSmithKline","keywords":"Naltrexone; Opioid; Opioid receptor; Single-nucleotide polymorphism; Internal medicine; Pharmacogenetics; Alcohol dependence; Genotype; Opioid antagonist; Placebo; Pharmacology; Medicine; Endocrinology; Psychology; Chemistry; Receptor; Alcohol; Genetics; Biology; Gene; (+)-Naloxone; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006557306,0.0002211229,0.0004221876,0.0001671708,0.00007410493,0.00001417695,0.0002225989,0.0001024919,0.00005589464],"category_scores_gemma":[0.0001113034,0.0001191238,0.00004758788,0.000300091,0.0004824095,0.00005830368,0.00006692314,0.0003285167,0.00001006733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003066344,"about_ca_system_score_gemma":0.00005527473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009711616,"about_ca_topic_score_gemma":0.00001845024,"domain_scores_codex":[0.997883,0.0006769917,0.0004193314,0.0004220205,0.0002098549,0.000388841],"domain_scores_gemma":[0.9983972,0.001021249,0.0001506053,0.0002988873,0.00002629223,0.0001057683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008940645,0.0003799398,0.05014732,0.0003456175,0.00008006475,0.0001427273,0.001333317,3.683713e-7,0.9043819,0.0004373522,0.01946853,0.01434226],"study_design_scores_gemma":[0.06745008,0.002432934,0.8819797,0.0001705043,0.0002339925,0.00004814838,0.0001634522,0.0001142481,0.01541139,0.000520865,0.0310843,0.0003903882],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772528,0.003549874,0.00001638527,0.01673887,0.0006316457,0.001523105,0.000008396908,0.00002024213,0.0002586305],"genre_scores_gemma":[0.9763925,0.01156392,0.00009097237,0.01141437,0.0001422548,0.0001083547,0.000006244196,0.00002524337,0.0002561426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8889705,"threshold_uncertainty_score":0.4857729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007273564077567339,"score_gpt":0.2719908045216537,"score_spread":0.2647172404440863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}