{"id":"W2345125968","doi":"10.1016/j.stemcr.2016.04.003","title":"A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production","year":2016,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Monash University","keywords":"Biology; Mesoderm; Induced pluripotent stem cell; Cell biology; Brachyury; mTORC1; PI3K/AKT/mTOR pathway; Endoderm; Embryonic stem cell; Embryoid body; Directed differentiation; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008021587,0.0003599641,0.0003269634,0.0001193315,0.000253272,0.00006634927,0.0001350126,0.0002605113,0.0000175871],"category_scores_gemma":[0.00002193904,0.0002749969,0.0001445024,0.0001261558,0.0001642205,0.00002823365,0.0002719067,0.000139702,0.00001821491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000483017,"about_ca_system_score_gemma":0.000110918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002857105,"about_ca_topic_score_gemma":0.00003375485,"domain_scores_codex":[0.9966676,0.0002145295,0.0007510398,0.001257289,0.0005312701,0.0005782522],"domain_scores_gemma":[0.9980944,0.000016701,0.0005110027,0.0008360987,0.0002821509,0.0002596634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004921534,0.0002869495,0.003222788,0.0002381902,0.00005199522,0.0002923307,0.00006133635,0.000002931713,0.9936484,0.000001243116,0.0006704136,0.001474229],"study_design_scores_gemma":[0.0008342938,0.0003696471,0.0009062861,0.000127573,0.00006086861,0.0003716897,0.00009229621,0.000004056574,0.9931563,0.000009218374,0.003693341,0.0003744718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947609,0.002161843,0.0004529839,0.00009504892,0.0002755399,0.001310954,0.0000270755,0.00005948521,0.0008561252],"genre_scores_gemma":[0.9602143,0.0004741111,0.0004172576,0.00001870261,0.000520966,0.0001487358,0.00007975867,0.00006523482,0.03806098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03720486,"threshold_uncertainty_score":0.9999702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762516893160219,"score_gpt":0.258218460130455,"score_spread":0.2405932911988528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}