{"id":"W2345149497","doi":"10.1182/blood.v120.21.97.97","title":"Functional Characterization of the Type 1 VWD Candidate VWF Gene Variants: P.M771I, p.L881R, p.P1413L, and p.Q1475X","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Von Willebrand factor; Von Willebrand disease; Molecular biology; Missense mutation; Biology; Complementary DNA; Gene; Mutation; Chemistry; Genetics; Immunology; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475268,0.0003470569,0.0002672052,0.000339372,0.0001354452,0.0002039881,0.000226125,0.000386996,0.001271938],"category_scores_gemma":[0.0003531097,0.00009166455,0.000380143,0.0002677903,0.0002673944,0.00007126825,0.0001293732,0.0002935597,0.0003548104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001945735,"about_ca_system_score_gemma":0.0001288396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008846915,"about_ca_topic_score_gemma":0.0005084617,"domain_scores_codex":[0.9998424,0.00002775937,0.00002789503,0.0000344672,0.00004475376,0.00002271407],"domain_scores_gemma":[0.9998512,0.00006731221,0.00003033395,0.00001002991,0.00001568131,0.00002543836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004707054,0.0001511979,0.01001409,0.00006537294,0.00002766328,0.004764382,0.0001363185,0.0002835561,0.9792337,0.000196401,0.0001050889,0.004551467],"study_design_scores_gemma":[0.0001264457,0.001028041,0.1107352,0.00002674165,0.0001628992,0.02326962,0.0002506313,0.004578745,0.8564612,0.0001635151,0.003173237,0.00002376674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982551,0.0001996286,0.0005901677,0.00003714214,0.00001002756,0.00001837896,0.0005034962,0.000008841817,0.0003773597],"genre_scores_gemma":[0.99778,0.0001512491,0.0007641352,0.00003485828,0.000006899041,0.00001524787,0.0008842752,0.00001571414,0.0003475449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001271938,"threshold_uncertainty_score":0.004255056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176843866214057,"score_gpt":0.2173973812340656,"score_spread":0.205628942571925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}