{"id":"W2345206408","doi":"10.1038/ncomms10961","title":"CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":231,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Center for Cell Signaling in Gastroenterology, Mayo Clinic; National Institutes of Health; Universitair Medisch Centrum Groningen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Jan Kornelis de Cock Stichting; Rijksuniversiteit Groningen; National Institute of Allergy and Infectious Diseases; Mayo Clinic","keywords":"Endosome; LDL receptor; Sorting; PCSK9; Chemistry; Endocytosis; Cell biology; Biology; Cholesterol; Receptor; Lipoprotein; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287379,0.0002719015,0.0001952779,0.0001887699,0.0002402146,0.0003506826,0.0001631372,0.0003248038,0.001081757],"category_scores_gemma":[0.0002204512,0.0001457336,0.0001716961,0.0001043442,0.0002892334,0.0001953658,0.0004846243,0.0003013593,0.0006579164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003885999,"about_ca_system_score_gemma":0.0002970163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008782194,"about_ca_topic_score_gemma":0.001053066,"domain_scores_codex":[0.9997858,0.00002541129,0.00002847379,0.00004250341,0.00007510692,0.00004266102],"domain_scores_gemma":[0.9997799,0.0000178905,0.00008303679,0.0000300357,0.00002923897,0.00005994843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000892714,0.000005827219,0.001057027,0.00003850214,0.000003863535,0.0001703074,0.00001065963,0.00003117178,0.9965217,0.0001640078,0.00008142809,0.00182628],"study_design_scores_gemma":[0.00002247911,0.00009899669,0.04138954,0.00001518492,0.00001431524,0.00152089,0.00006408088,0.001050422,0.949181,0.0001142158,0.006518475,0.00001025735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921564,0.002129911,0.003434703,0.000154831,0.00002907804,0.00001365727,0.0003987839,0.0001712936,0.001511284],"genre_scores_gemma":[0.9956861,0.0005290012,0.001658034,0.00004134746,0.000009808668,0.00001294748,0.0005524785,0.0000215241,0.001488741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001081757,"threshold_uncertainty_score":0.003618836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100356625968633,"score_gpt":0.2686564301895194,"score_spread":0.2476528639298331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}