{"id":"W2345206408","doi":"10.1038/ncomms10961","title":"CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":231,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Center for Cell Signaling in Gastroenterology, Mayo Clinic; National Institutes of Health; Universitair Medisch Centrum Groningen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Jan Kornelis de Cock Stichting; Rijksuniversiteit Groningen; National Institute of Allergy and Infectious Diseases; Mayo Clinic","keywords":"Endosome; LDL receptor; Sorting; PCSK9; Chemistry; Endocytosis; Cell biology; Biology; Cholesterol; Receptor; Lipoprotein; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002065384,0.00008804968,0.0002414739,0.00003997564,0.0001718107,0.000003401262,0.0003552814,0.0002544417,0.00001960512],"category_scores_gemma":[0.0004299173,0.00006713995,0.0001800037,0.00008953793,0.0003422943,0.00007748368,0.0001678563,0.000170698,0.000004034707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001005839,"about_ca_system_score_gemma":0.00003424676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001125725,"about_ca_topic_score_gemma":0.0000117518,"domain_scores_codex":[0.9992486,0.0001269683,0.0003019845,0.0001381468,0.00003567329,0.0001486155],"domain_scores_gemma":[0.9982723,0.0004989341,0.0002377398,0.0007987339,0.0001770482,0.0000152484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005410672,0.00009325928,0.0220233,0.00003676128,0.0002896739,4.661991e-8,0.0003442146,6.330533e-7,0.9599525,0.003435492,0.0002782446,0.01349174],"study_design_scores_gemma":[0.008356436,0.0002628622,0.6609493,0.0008753033,0.0005882222,0.00002966284,0.0009934857,0.0001110834,0.2977067,0.0007490101,0.02880924,0.0005685887],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518532,0.04568741,0.0004361432,0.0008050366,0.0001025665,0.0003087746,0.0003405832,0.00003590911,0.0004304099],"genre_scores_gemma":[0.9978316,0.001063282,0.0008493031,0.00008195393,0.00001102984,0.00003117107,0.00005713475,0.00001246213,0.00006209942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6622458,"threshold_uncertainty_score":0.2737888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100356625968633,"score_gpt":0.2686564301895194,"score_spread":0.2476528639298331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}