{"id":"W2345256317","doi":"10.2174/1566524016666160429115834","title":"Lysosomal Acid Phosphatase Biosynthesis and Dysfunction: A Mini Review Focused on Lysosomal Enzyme Dysfunction in Brain","year":2016,"lang":"en","type":"review","venue":"Current Molecular Medicine","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Lysosome; Lysosomal storage disease; Neuronal ceroid lipofuscinosis; Mannose 6-phosphate receptor; Lipofuscin; Acid phosphatase; Glucocerebrosidase; Enzyme; Biology; Pathogenesis; Batten disease; Disease; Biochemistry; Cell biology; Gene; Medicine; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003164185,0.0008802635,0.001313588,0.0026467,0.0002823475,0.001088749,0.0006379754,0.00100077,0.006341935],"category_scores_gemma":[0.0005826906,0.0002471977,0.0006074306,0.002662564,0.0002849406,0.001495669,0.0006853205,0.001288997,0.002967361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006038639,"about_ca_system_score_gemma":0.001395181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008534127,"about_ca_topic_score_gemma":0.001388632,"domain_scores_codex":[0.9998529,0.00001997965,0.00003511018,0.00002384428,0.0000495837,0.00001853581],"domain_scores_gemma":[0.9997661,0.00007550861,0.00004435283,0.000005798152,0.00008095147,0.00002740942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001279329,0.00009170566,0.0003020669,0.03522189,0.0001561375,0.0007212129,0.0001142881,0.0002963221,0.004337165,0.003566529,0.1001645,0.8549002],"study_design_scores_gemma":[0.00001590681,0.00008522783,0.0007488296,0.004437289,0.0001922099,0.003246554,0.00007071089,0.00007232096,0.001007594,0.00142115,0.9886783,0.00002390024],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001216351,0.9982371,0.00009108157,0.0003043961,0.0003775041,0.000005036576,0.00003448341,0.00000787797,0.0008209449],"genre_scores_gemma":[0.0005125668,0.9980093,0.0002029568,0.0001915056,0.0003404501,0.000006363445,0.00006526156,0.00000203139,0.0006695966],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006341935,"threshold_uncertainty_score":0.02121586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05019188280752647,"score_gpt":0.3541735610778177,"score_spread":0.3039816782702912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}