{"id":"W2345311615","doi":"10.1212/wnl.84.14_supplement.p7.198","title":"Efficacy Results of the Phase 2 Portion of the RADIANCE Trial: A Randomized, Double-blind, Placebo-controlled Trial of Oral RPC1063 in Adults with Relapsing Multiple Sclerosis (P7.198)","year":2015,"lang":"en","type":"article","venue":"Neurology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Placebo; Double blind; Medicine; Randomized controlled trial; Multiple sclerosis; Radiance; Clinical trial; Surgery; Internal medicine; Psychiatry; Alternative medicine; Pathology; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001318857,0.0001624865,0.001147519,0.0001614377,0.00003934784,0.000004265188,0.000173818,0.000142548,0.00001069161],"category_scores_gemma":[0.003822688,0.00008483802,0.0003719989,0.0003941536,0.0003186933,0.00006637031,0.00004129702,0.0004123326,8.440531e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002179147,"about_ca_system_score_gemma":0.0002439933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009042284,"about_ca_topic_score_gemma":0.00040522,"domain_scores_codex":[0.9972304,0.0007421093,0.001234588,0.0002691236,0.0003306162,0.0001931994],"domain_scores_gemma":[0.996888,0.001073882,0.001190385,0.0005219696,0.0002600595,0.00006574214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9865572,0.001456672,0.0001003892,0.00001594917,0.0000992265,0.000003838962,0.0006627212,0.0007829901,0.009868111,0.00004193567,0.000122482,0.0002884626],"study_design_scores_gemma":[0.9766869,0.006910065,0.0001341959,0.000236039,0.0003023371,0.00001992213,0.0000261719,0.002681088,0.01275905,0.00001315836,0.0001688448,0.00006220052],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890972,0.00005078417,0.00002879341,0.00228557,0.00111912,0.007026708,0.0000180093,0.00001368869,0.0003601548],"genre_scores_gemma":[0.9993525,0.00001768372,0.00006013149,0.0001641702,0.0001321764,0.0002023416,0.000009947968,0.00001954138,0.00004149573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01025534,"threshold_uncertainty_score":0.4576391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07659430185755242,"score_gpt":0.3141208278167646,"score_spread":0.2375265259592122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}