{"id":"W2345311615","doi":"10.1212/wnl.84.14_supplement.p7.198","title":"Efficacy Results of the Phase 2 Portion of the RADIANCE Trial: A Randomized, Double-blind, Placebo-controlled Trial of Oral RPC1063 in Adults with Relapsing Multiple Sclerosis (P7.198)","year":2015,"lang":"en","type":"article","venue":"Neurology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Placebo; Double blind; Medicine; Randomized controlled trial; Multiple sclerosis; Radiance; Clinical trial; Surgery; Internal medicine; Psychiatry; Alternative medicine; Pathology; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016751,0.001756866,0.00230807,0.0002912648,0.0004320481,0.0006821813,0.0006805508,0.001555723,0.006057412],"category_scores_gemma":[0.001479581,0.0005728839,0.001062726,0.0002323552,0.0008602704,0.000719949,0.0002936014,0.002357768,0.0009574586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004156659,"about_ca_system_score_gemma":0.0008191035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000414314,"about_ca_topic_score_gemma":0.0009391338,"domain_scores_codex":[0.999418,0.0003523642,0.00003237136,0.00008480897,0.00004277701,0.00006961694],"domain_scores_gemma":[0.9992231,0.0001882484,0.0002363491,0.00005624881,0.00005684183,0.0002391955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9749916,0.00668712,0.0004767072,0.0003278368,0.0004311131,0.00003280858,0.00003366724,0.000143315,0.004403421,0.00005286931,0.0008319434,0.01158769],"study_design_scores_gemma":[0.9293481,0.06757341,0.00196198,0.00001718504,0.0002306306,0.00003136808,0.000007896993,0.0001308872,0.0003276022,0.00003870103,0.0003238596,0.000008411069],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903978,0.002797346,0.000400994,0.0004841623,0.0001974578,0.002822753,0.001046913,0.0001349018,0.001717736],"genre_scores_gemma":[0.9830472,0.002376872,0.002273278,0.001221879,0.0005695528,0.005412966,0.001954473,0.00004089622,0.003102968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006057412,"threshold_uncertainty_score":0.02026409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07659430185755242,"score_gpt":0.3141208278167646,"score_spread":0.2375265259592122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}