{"id":"W2345365860","doi":"10.1161/atvb.32.suppl_1.a432","title":"Abstract 432: MEK/ERK Inhibition Corrects the Defect in VLDL Assembly and Secretion in HepG2 Cells via Activation of Cell Death--Inducing DFFA-Like Effector B (Cide B), ApoCIII and Lipin-1","year":2012,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; University of Ottawa; Hospital for Sick Children","funders":"","keywords":"MAPK/ERK pathway; Secretion; MEK inhibitor; Gene knockdown; Endocrinology; Internal medicine; Cell biology; Intracellular; Apolipoprotein B; Chemistry; Very low-density lipoprotein; Biology; Signal transduction; Biochemistry; Medicine; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281057,0.0005161423,0.0003530621,0.0001791781,0.000164226,0.0003969311,0.0001898475,0.0001872046,0.003241613],"category_scores_gemma":[0.00007198715,0.0001569276,0.0002930891,0.0001592345,0.0001968794,0.0001509852,0.0001839934,0.0007873902,0.00108046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003212634,"about_ca_system_score_gemma":0.0004269948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001172232,"about_ca_topic_score_gemma":0.001320488,"domain_scores_codex":[0.9998689,0.0000195278,0.00001739222,0.00001982117,0.00003742355,0.00003695544],"domain_scores_gemma":[0.9999486,0.000006284906,0.000009898121,0.000008499213,0.00000724781,0.00001942467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003723556,0.00008591403,0.00009152568,0.00006060306,0.000008130101,0.00005944625,0.000009916158,0.00005735697,0.9975561,0.00008320215,0.0002091141,0.001406309],"study_design_scores_gemma":[0.00006273493,0.0001994237,0.00167701,0.000003903695,0.00001399624,0.0001762676,0.00001981602,0.0007798049,0.9937083,0.00002432276,0.003330728,0.000003744679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880937,0.001511876,0.003046297,0.0003698389,0.0002092321,0.00006929482,0.002097392,0.0004213349,0.004181194],"genre_scores_gemma":[0.9816703,0.0009642086,0.002739243,0.0001186725,0.00002971175,0.00008807366,0.002237542,0.00007567455,0.0120766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003241613,"threshold_uncertainty_score":0.01084423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01665526201560176,"score_gpt":0.2487154162334394,"score_spread":0.2320601542178377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}