{"id":"W2345457773","doi":"10.1016/j.lfs.2016.05.010","title":"The isolated human umbilical vein as a bioassay for kinin-generating proteases: An in vitro model for therapeutic angioedema agents","year":2016,"lang":"en","type":"article","venue":"Life Sciences","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Proteases; Kallikrein; Kinin; Kininogen; Bradykinin; Umbilical vein; Plasmin; Chemistry; High-molecular-weight kininogen; Pharmacology; Biochemistry; Kallidin; Bioassay; Receptor; Biological activity; In vitro; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006578806,0.0005695766,0.0003091481,0.0004059161,0.0002656793,0.000567815,0.0005300134,0.0003822948,0.002010663],"category_scores_gemma":[0.0004263385,0.0001921619,0.0003635708,0.0003481098,0.0004080357,0.0005274357,0.0002152076,0.00120568,0.0005602115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000278293,"about_ca_system_score_gemma":0.0003345413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005770653,"about_ca_topic_score_gemma":0.0008334689,"domain_scores_codex":[0.9995309,0.0002668778,0.00003305155,0.00005009953,0.00007137808,0.00004770048],"domain_scores_gemma":[0.9996327,0.0001749027,0.00003593608,0.00008209322,0.00002888966,0.00004544241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005201779,0.0003247702,0.0004314142,0.0001738146,0.00002219357,0.000490306,0.00007029941,0.0001684469,0.9918422,0.001205285,0.0002580298,0.004493067],"study_design_scores_gemma":[0.00004921262,0.001408799,0.001694447,0.00002642263,0.00006931321,0.001055416,0.00005354833,0.001839494,0.9903185,0.0002378457,0.003239715,0.000007242474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.837633,0.0171606,0.1309393,0.0007528264,0.0007560519,0.00056068,0.001139193,0.0002393245,0.01081894],"genre_scores_gemma":[0.9539154,0.006127754,0.0346019,0.0002192253,0.0001533655,0.000258503,0.0008045372,0.00004676867,0.003872418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002010663,"threshold_uncertainty_score":0.006726384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08524765250212106,"score_gpt":0.3701905610339698,"score_spread":0.2849429085318487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}