{"id":"W2345701398","doi":"10.1210/en.2016-1102","title":"Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin","year":2016,"lang":"en","type":"article","venue":"Endocrinology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Insulin; Adipose tissue; Brown adipose tissue; Biology; Hormone; Respiratory exchange ratio; Thermogenesis; Carbohydrate metabolism; Pancreatic hormone; Insulin resistance; Medicine; Blood pressure; Heart rate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002326185,0.0008714749,0.0005272093,0.0009006316,0.0002404117,0.0006281353,0.0003966015,0.0005379951,0.002435612],"category_scores_gemma":[0.000151147,0.0005231256,0.0005213261,0.000409448,0.0006463447,0.0003093619,0.000388273,0.001701882,0.0006239994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003309472,"about_ca_system_score_gemma":0.0002680115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007485228,"about_ca_topic_score_gemma":0.001824558,"domain_scores_codex":[0.9996529,0.00003724548,0.00004473615,0.0001042865,0.00008028575,0.00008056885],"domain_scores_gemma":[0.9995005,0.00003366187,0.0002202768,0.00005567621,0.00002360744,0.0001662396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000529294,0.00007451968,0.0003966728,0.00002518216,0.0000106143,0.00007392884,0.00002034606,0.00005027733,0.9980267,0.0001056857,0.00005681407,0.0006299308],"study_design_scores_gemma":[0.000401757,0.002390374,0.05380987,0.00006411313,0.0001732202,0.002093333,0.0003304297,0.002097009,0.9336079,0.0004818368,0.0044902,0.00005992819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956317,0.0005950971,0.001430259,0.0002165398,0.0000484046,0.00002177588,0.0009780136,0.0002201601,0.0008580372],"genre_scores_gemma":[0.9817923,0.001637617,0.004616716,0.0004289825,0.00005266779,0.0001633265,0.001831839,0.0003005943,0.009175901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002435612,"threshold_uncertainty_score":0.008147955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008972486791455968,"score_gpt":0.2227815726157516,"score_spread":0.2138090858242956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}