{"id":"W2345759082","doi":"10.1002/1873-3468.12198","title":"Paraoxonase 1‐treated ox<scp>LDL</scp> promotes cholesterol efflux from macrophages by stimulating the <scp>PPAR</scp>γ–<scp>LXR</scp>α–<scp>ABCA</scp>1 pathway","year":2016,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Paraoxonase enzyme and polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cholesterol; Efflux; Liver X receptor; Cell biology; Biochemistry; Biology; Nuclear receptor; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630428,0.0002696292,0.0003471586,0.0001747417,0.0001437582,0.000278938,0.0001290708,0.0002699047,0.00287964],"category_scores_gemma":[0.0001228627,0.0001209155,0.0002455136,0.0001208908,0.0002868658,0.000208869,0.0001319471,0.0007684456,0.0004135459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390275,"about_ca_system_score_gemma":0.0002452221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006653291,"about_ca_topic_score_gemma":0.0008869882,"domain_scores_codex":[0.99989,0.00001708259,0.000007985508,0.00002445158,0.00002583535,0.00003458326],"domain_scores_gemma":[0.9998972,0.00001606772,0.00002875082,0.000012163,0.00001683026,0.00002895814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004206405,0.00005515816,0.0002881401,0.00003516054,0.00000582945,0.00005827246,0.00002121214,0.0000127374,0.9978753,0.00004709993,0.00003573963,0.001144654],"study_design_scores_gemma":[0.00002619125,0.0005299847,0.00406035,0.000003013727,0.00001283819,0.0001677614,0.0000360141,0.000180459,0.9936345,0.00005694925,0.001288838,0.000003198333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960914,0.0007823593,0.002003073,0.0001983015,0.00006087358,0.00002430416,0.0002068957,0.00003785704,0.0005948495],"genre_scores_gemma":[0.9918603,0.0007514758,0.002191572,0.0001082718,0.00003085742,0.00004147939,0.0006207272,0.00001733836,0.004377885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00287964,"threshold_uncertainty_score":0.009633362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009682865114674125,"score_gpt":0.2214914888964295,"score_spread":0.2118086237817554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}