{"id":"W2345912905","doi":"10.1016/j.jid.2016.04.020","title":"Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways","year":2016,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Medical Research Council","keywords":"Filaggrin; Protein kinase B; PI3K/AKT/mTOR pathway; Cell biology; Biology; Bone morphogenetic protein; Signal transduction; Phosphoinositide 3-kinase; Protein kinase A; Phosphorylation; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002960897,0.0001603991,0.0002862833,0.00008472852,0.0001113853,0.00001792182,0.0001720198,0.0002212981,0.00002318613],"category_scores_gemma":[0.0006181984,0.0001070229,0.00008574178,0.0000591268,0.0005646423,0.000015546,0.0001105945,0.0001529656,0.000003574826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000014826,"about_ca_system_score_gemma":0.00007296594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002223428,"about_ca_topic_score_gemma":0.000001397293,"domain_scores_codex":[0.9985255,0.000390444,0.0004510586,0.0002234316,0.0001336132,0.0002759353],"domain_scores_gemma":[0.9989489,0.0001208508,0.0003959406,0.0001367202,0.0002301413,0.0001674853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005456341,0.0000230104,0.01088004,0.00001396927,0.0001013594,0.00003696828,0.00008182148,0.000002672002,0.9853138,0.0002353038,0.001566625,0.001689882],"study_design_scores_gemma":[0.000843503,0.0002302507,0.003684487,0.00005268477,0.00001934806,0.00183155,0.00009881163,0.0000713532,0.9894882,0.002937517,0.0006037395,0.0001385492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932221,0.001881549,0.003139025,0.001516603,0.00008433349,0.00007344749,0.000012627,0.000004991417,0.00006538421],"genre_scores_gemma":[0.9985603,0.000170709,0.0008114881,0.0002082853,0.0001281412,0.000002822433,0.00002349569,0.00001751724,0.00007724355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007195548,"threshold_uncertainty_score":0.4364266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01927286562582938,"score_gpt":0.2456876851188235,"score_spread":0.2264148194929941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}