{"id":"W2345927750","doi":"10.1007/s11912-016-0522-0","title":"Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)","year":2016,"lang":"en","type":"review","venue":"Current Oncology Reports","topic":"Nutrition and Health in Aging","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Wasting; Medicine; Cachexia; Clinical trial; Cancer; Placebo; Sarcopenia; Wasting Syndrome; Internal medicine; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05645782,0.00379901,0.005644724,0.002013882,0.003063404,0.003548334,0.003626531,0.005753437,0.04125164],"category_scores_gemma":[0.05104639,0.00259491,0.004100299,0.002699064,0.00345012,0.002662907,0.002417537,0.006950997,0.01502413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002547491,"about_ca_system_score_gemma":0.01384035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001432901,"about_ca_topic_score_gemma":0.002985594,"domain_scores_codex":[0.9702685,0.01875997,0.002700308,0.003073807,0.003564717,0.001632708],"domain_scores_gemma":[0.9829203,0.005014482,0.002287297,0.003166827,0.004039226,0.002571795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.5286881,0.02083236,0.008720525,0.02660467,0.003353093,0.001097353,0.001317932,0.002507206,0.006515744,0.04418123,0.0800449,0.2761369],"study_design_scores_gemma":[0.4675061,0.08582736,0.01217562,0.01000778,0.004218529,0.0006634228,0.0004671465,0.003761337,0.003245656,0.02710158,0.3846318,0.0003937448],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.00461685,0.003903963,0.01200119,0.002342169,0.002300528,0.9637377,0.004044363,0.0001679413,0.006885306],"genre_scores_gemma":[0.007645018,0.001132465,0.01784116,0.002880607,0.0004306338,0.9670979,0.0007606493,0.0000345107,0.00217701],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05645782,"threshold_uncertainty_score":0.2985811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5401257895311953,"score_gpt":0.6061589434393678,"score_spread":0.06603315390817255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}