{"id":"W2345927750","doi":"10.1007/s11912-016-0522-0","title":"Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)","year":2016,"lang":"en","type":"review","venue":"Current Oncology Reports","topic":"Nutrition and Health in Aging","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Wasting; Medicine; Cachexia; Clinical trial; Cancer; Placebo; Sarcopenia; Wasting Syndrome; Internal medicine; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003673491,0.0001950339,0.001623111,0.00009666054,0.0001172056,0.000005092085,0.00003386612,0.0001389889,0.000009047749],"category_scores_gemma":[0.0008676145,0.00009420617,0.0002045369,0.00009891168,0.00009456898,0.00002308773,0.00002312945,0.000108793,6.613183e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263329,"about_ca_system_score_gemma":0.001581179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002192877,"about_ca_topic_score_gemma":0.00001000228,"domain_scores_codex":[0.9966839,0.0005427513,0.002087719,0.0003715275,0.0001443837,0.0001697268],"domain_scores_gemma":[0.9942259,0.003290727,0.001949979,0.0001457,0.0003214714,0.0000662579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002954384,0.008098672,0.004401972,0.002458714,0.0004294404,0.00000148258,0.0006931289,1.922658e-7,5.808722e-7,0.000001819178,0.0001986068,0.98342],"study_design_scores_gemma":[0.01231167,0.009091654,0.002293164,0.007277662,0.001882976,0.00001849638,0.0001221225,0.00003680644,0.00001381139,0.00003844745,0.9668037,0.0001094527],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02307954,0.9386933,0.0008352509,0.0000750315,0.0009405301,0.03632665,0.00003861259,0.000009278238,0.000001799156],"genre_scores_gemma":[0.00431308,0.9739918,0.002524626,0.000006363725,0.0001883162,0.01885054,0.00008214406,0.00002174493,0.00002134941],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9833105,"threshold_uncertainty_score":0.3841616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5401257895311953,"score_gpt":0.6061589434393678,"score_spread":0.06603315390817255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}