{"id":"W2345966590","doi":"10.1038/nature17668","title":"Activation of the A2A adenosine G-protein-coupled receptor by conformational selection","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":365,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Allosteric regulation; Chemistry; Agonist; G protein-coupled receptor; Inverse agonist; Population; Partial agonist; Biophysics; Receptor; Adenosine A2A receptor; Ligand (biochemistry); Adenosine receptor; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008448141,0.00006400638,0.00005323425,0.00001264655,0.00005271111,0.000007365669,0.00009670147,0.0004893449,0.0002491385],"category_scores_gemma":[0.00008170458,0.00003541495,0.00004686158,0.00006392581,0.00001878968,0.000008102113,0.00002248645,0.0001752878,0.000003289261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001387444,"about_ca_system_score_gemma":0.00003619265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003587535,"about_ca_topic_score_gemma":0.000001282724,"domain_scores_codex":[0.9995555,0.00002110219,0.0001048946,0.0001031208,0.0001369043,0.00007848861],"domain_scores_gemma":[0.9996606,0.000006109502,0.0000972658,0.00009444886,0.000124384,0.00001720165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000398257,0.00001030844,0.00008432483,0.000004494399,0.00001307596,3.85383e-9,0.00000693054,0.000002922451,0.9899722,0.0005637747,0.008252291,0.001049891],"study_design_scores_gemma":[0.0002765667,0.00005510985,0.0002032235,0.00002519892,0.000002718695,8.056822e-7,0.000009865508,0.00002865915,0.9683629,0.00009658437,0.03088366,0.00005472957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929481,0.0001518122,0.005470121,0.0009192089,0.0001604337,0.0001501192,0.00002137594,0.000006183051,0.000172621],"genre_scores_gemma":[0.9980628,0.00001483179,0.0003105443,0.000194764,0.0001452034,0.000009020886,0.00005396572,0.000007154328,0.001201709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02263137,"threshold_uncertainty_score":0.3774276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003245916053936517,"score_gpt":0.2087739117015331,"score_spread":0.2055279956475966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}