{"id":"W2345968067","doi":"10.1016/j.canlet.2016.05.004","title":"Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes","year":2016,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Cancer Institute; CancerCare Manitoba Foundation; National Institutes of Health; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Pentose phosphate pathway; Biology; Glycolysis; Histone methyltransferase; Transketolase; Cancer research; Epigenetics; Methyltransferase; Biochemistry; Enzyme; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606824,0.0001780276,0.0002059616,0.00004798057,0.00005874443,0.00001153617,0.0001446425,0.00007115237,0.00004868028],"category_scores_gemma":[0.00006023776,0.0001455185,0.00009346828,0.0001210723,0.0001266347,0.00001397881,0.00002836138,0.00005336995,0.000001455426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004268747,"about_ca_system_score_gemma":0.00003680025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001013796,"about_ca_topic_score_gemma":0.00002184523,"domain_scores_codex":[0.9987805,0.00008258958,0.0003179419,0.0004151262,0.0001532357,0.0002506046],"domain_scores_gemma":[0.9992657,0.00002765569,0.0001871509,0.0003344856,0.0001124304,0.00007252478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001710501,0.00003236096,0.0006644722,0.00002544845,0.00006999284,0.00000140123,0.00007205575,0.00001572896,0.9609723,0.00003553796,0.000941588,0.03699806],"study_design_scores_gemma":[0.0007950405,0.0000417949,0.0006747526,0.00003811146,0.00002696955,2.36092e-7,0.000008446923,0.000002653262,0.8958412,0.00003243155,0.1023583,0.0001801011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9156252,0.01523204,0.06652448,0.002010013,0.0002085988,0.0002295754,0.00006819498,0.0000191689,0.00008278101],"genre_scores_gemma":[0.9956875,0.001744797,0.0008903083,0.00031835,0.0001183245,0.00008003883,0.00008623594,0.00003114267,0.001043316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1014167,"threshold_uncertainty_score":0.5934073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006751903101333528,"score_gpt":0.2556575792422621,"score_spread":0.2489056761409285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}