{"id":"W2345972868","doi":"10.1634/theoncologist.2015-0336","title":"The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer","year":2016,"lang":"en","type":"article","venue":"The Oncologist","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Canadian Institutes of Health Research; National Institute for Health and Care Research; National Cancer Institute; Ovarian Cancer Research Fund; National Institutes of Health; Cancer Research UK; American Society of Clinical Oncology; National Institute for Health and Care Excellence; Royal Marsden NHS Foundation Trust; Breast Cancer Research Foundation; U.S. Department of Defense","keywords":"Medicine; Prostate cancer; Oncology; Prostate cancer screening; Family history; Internal medicine; Prostate-specific antigen; Logistic regression; Population; Single-nucleotide polymorphism; Prostate; Gynecology; Cancer; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001401568,0.00067137,0.0004131477,0.0004019373,0.0004995696,0.0003024718,0.0004072579,0.0004641798,0.002289833],"category_scores_gemma":[0.003074981,0.0003645238,0.0005470779,0.000223711,0.0003147193,0.000508462,0.0007432108,0.0005681958,0.0004330926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449819,"about_ca_system_score_gemma":0.0008135337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310175,"about_ca_topic_score_gemma":0.001622827,"domain_scores_codex":[0.9994018,0.000368011,0.00002506607,0.00009951332,0.00005315938,0.0000524647],"domain_scores_gemma":[0.9987274,0.0004357862,0.0002424854,0.000127618,0.0001102946,0.0003564855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05785552,0.01065219,0.8719963,0.0003134401,0.0004629134,0.002017789,0.0005063877,0.0007154879,0.00796629,0.00021642,0.001175357,0.046122],"study_design_scores_gemma":[0.01462573,0.1501613,0.81898,0.00005746969,0.0006066991,0.006011571,0.0003897458,0.00260805,0.003511655,0.0005422817,0.00244185,0.00006377065],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970187,0.0001801915,0.0007553826,0.0001115622,0.00001178243,0.0007192901,0.0003183544,0.0000130314,0.0008717976],"genre_scores_gemma":[0.9971313,0.0001350227,0.001314611,0.0001580144,0.00003499055,0.0005364705,0.0003726208,0.000004832867,0.00031212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002289833,"threshold_uncertainty_score":0.00766027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05336829173518951,"score_gpt":0.3218246425786746,"score_spread":0.2684563508434851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}