{"id":"W2345977364","doi":"10.1038/srep25596","title":"FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; School of Medicine, New York University; York University; Office of Research and Development; U.S. Department of Veterans Affairs","keywords":"Carcinogenesis; Cancer research; Urothelium; Urothelial Cell; Biology; Missense mutation; Mutation; Genetically modified mouse; Cell growth; Protein kinase B; Transgene; Cancer; Phosphorylation; Gene; Cell biology; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296328,0.0005768929,0.0003419622,0.0003801903,0.0002382739,0.000350308,0.000292922,0.0005192611,0.001477897],"category_scores_gemma":[0.0001930244,0.0002843642,0.0004545492,0.0002096895,0.0003317793,0.0001862673,0.0002581464,0.0008322067,0.0006006815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089525,"about_ca_system_score_gemma":0.0003375896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251329,"about_ca_topic_score_gemma":0.001397763,"domain_scores_codex":[0.9997042,0.00005073428,0.00004498398,0.00004730751,0.00008213387,0.00007066829],"domain_scores_gemma":[0.9997003,0.00004462918,0.00007814899,0.00005214203,0.00001604254,0.0001087397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005789344,0.00004219355,0.0001344205,0.0000135398,0.000004515468,0.00009201709,0.000008240641,0.0000385837,0.9992164,0.00005294332,0.00002838753,0.0003107933],"study_design_scores_gemma":[0.0000281441,0.0004500656,0.003581521,0.000004701001,0.00001718306,0.0008545046,0.0000241129,0.0009700471,0.9926623,0.00004434729,0.001357863,0.000005136627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960865,0.0005938747,0.001603143,0.0001030019,0.00003135778,0.0000401673,0.0005369546,0.0001752887,0.000829791],"genre_scores_gemma":[0.9960983,0.0003279316,0.0007820432,0.00003206782,0.000006304407,0.00004274448,0.0006529696,0.00003996778,0.002017666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477897,"threshold_uncertainty_score":0.004944086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506063733831238,"score_gpt":0.2519515089122076,"score_spread":0.2368908715738953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}