{"id":"W2346042270","doi":"10.18632/oncotarget.8281","title":"[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Sorafenib; Pemetrexed; Medicine; Lapatinib; Pharmacology; Cancer research; Afatinib; Dasatinib; Kinase; Erlotinib; Internal medicine; Cancer; Chemistry; Breast cancer; Epidermal growth factor receptor; Imatinib; Cisplatin; Trastuzumab; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436601,0.0002275032,0.0002832702,0.0001156469,0.00008420287,0.0002222266,0.0001014031,0.0001024859,0.00274144],"category_scores_gemma":[0.0001646048,0.00007986767,0.000214838,0.0000808146,0.0001352746,0.0001060393,0.0001312558,0.0003610978,0.0002784169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001671248,"about_ca_system_score_gemma":0.000248197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002974663,"about_ca_topic_score_gemma":0.0007210435,"domain_scores_codex":[0.999903,0.00002630952,0.000006761587,0.00001280424,0.00002330523,0.00002776847],"domain_scores_gemma":[0.9999201,0.00001140018,0.00003145598,0.000008162708,0.000004019698,0.00002483383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009645196,0.0007190506,0.003006188,0.0001849298,0.00007366951,0.0002857003,0.00002740778,0.000760609,0.9529309,0.000326967,0.001066365,0.03097293],"study_design_scores_gemma":[0.001838974,0.04649171,0.1018674,0.00006083868,0.0001873928,0.003610514,0.0001671628,0.005674416,0.8262526,0.0005111426,0.01330502,0.0000328078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967496,0.0007958972,0.0005540852,0.0001105922,0.00003621774,0.00002586615,0.0002397652,0.00005326009,0.001434666],"genre_scores_gemma":[0.9981875,0.0003264018,0.0002350942,0.00004311244,0.000009100919,0.00001733868,0.0002344786,0.000005930983,0.0009411249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00274144,"threshold_uncertainty_score":0.009171009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170801878479051,"score_gpt":0.2588695901190857,"score_spread":0.2417894022711806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}