{"id":"W2346262847","doi":"10.1016/j.celrep.2016.04.032","title":"The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Labex Immuno-Oncology; Genentech; European Research Council; Vlaamse regering; Vlaams Instituut voor Biotechnologie; Universiteit Gent; Ligue Contre le Cancer; Fonds Wetenschappelijk Onderzoek; Österreichischen Akademie der Wissenschaften; Vienna Science and Technology Fund; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Commission; Institut National Du Cancer; Max-Planck-Gesellschaft; Agence Nationale pour le Développement de la Recherche en Santé; Deutsche Forschungsgemeinschaft; AstraZeneca; Leona M. and Harry B. Helmsley Charitable Trust; National Science Foundation","keywords":"Regulator; Cell fate determination; Suppressor; Cell biology; Chemistry; Master regulator; Cell; Biology; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424573,0.0003538083,0.0002251854,0.0002054194,0.0002100919,0.0003809538,0.0001837891,0.0002425344,0.0011566],"category_scores_gemma":[0.0001567562,0.0001309291,0.000162247,0.0001426322,0.0002340278,0.0002197949,0.0002968385,0.0004238726,0.0006723246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003417333,"about_ca_system_score_gemma":0.0001670446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001745948,"about_ca_topic_score_gemma":0.0002042806,"domain_scores_codex":[0.9998918,0.000015912,0.00001021374,0.00002619901,0.00003341076,0.00002245194],"domain_scores_gemma":[0.9998158,0.00001697599,0.00007941776,0.00001921589,0.000023806,0.00004484579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008188366,0.000008134493,0.000517305,0.00002662593,0.000003965085,0.0001395957,0.000007505505,0.00007586033,0.9969677,0.0002061836,0.00005832161,0.00190692],"study_design_scores_gemma":[0.00001213621,0.00009419334,0.007772937,0.000004830936,0.000009047179,0.001454818,0.00002682181,0.0009112608,0.9838635,0.0001215353,0.005723708,0.000005305993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982854,0.00641976,0.00767167,0.000260585,0.00004461069,0.00002088884,0.0006121643,0.0002138203,0.001902454],"genre_scores_gemma":[0.9945289,0.001169959,0.001487048,0.00003112589,0.000009834648,0.000009968584,0.0005789984,0.00002060708,0.002163486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0011566,"threshold_uncertainty_score":0.003869236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005577043534267185,"score_gpt":0.2219715203103723,"score_spread":0.2163944767761052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}