{"id":"W2346262847","doi":"10.1016/j.celrep.2016.04.032","title":"The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Labex Immuno-Oncology; Genentech; European Research Council; Vlaamse regering; Vlaams Instituut voor Biotechnologie; Universiteit Gent; Ligue Contre le Cancer; Fonds Wetenschappelijk Onderzoek; Österreichischen Akademie der Wissenschaften; Vienna Science and Technology Fund; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Commission; Institut National Du Cancer; Max-Planck-Gesellschaft; Agence Nationale pour le Développement de la Recherche en Santé; Deutsche Forschungsgemeinschaft; AstraZeneca; Leona M. and Harry B. Helmsley Charitable Trust; National Science Foundation","keywords":"Regulator; Cell fate determination; Suppressor; Cell biology; Chemistry; Master regulator; Cell; Biology; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002571588,0.0001411641,0.0001429781,0.00002148467,0.000102493,0.00001772908,0.0001083761,0.0001332487,0.00009403316],"category_scores_gemma":[0.000162222,0.00007965873,0.0001273314,0.0000499278,0.0001558357,0.000004086029,0.00009531512,0.00004320124,0.00001142265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000957638,"about_ca_system_score_gemma":0.00007635298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006829152,"about_ca_topic_score_gemma":0.00000286365,"domain_scores_codex":[0.9987529,0.00004089533,0.0003880775,0.0003554613,0.0001985836,0.0002640628],"domain_scores_gemma":[0.9988431,0.00005532623,0.0002077405,0.0006322712,0.0001571662,0.0001043991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003568766,0.00005035108,0.0002276673,0.00002736295,0.000009356397,0.00004235422,0.00001687477,0.000001809524,0.99253,0.00006511882,0.006397464,0.0005959135],"study_design_scores_gemma":[0.0002198131,0.0001068626,0.0006383329,0.00001626507,0.00001956277,0.00005446771,0.00002176995,0.00003228427,0.8895953,0.0004009575,0.1087732,0.0001212525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899801,0.001704739,0.001970062,0.0006287819,0.0006144444,0.000293936,0.00002484951,0.00002070575,0.004762406],"genre_scores_gemma":[0.9890856,0.000172945,0.0002642105,0.00008297202,0.0001309112,0.00001551044,0.00002261839,0.00002542856,0.01019986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1029348,"threshold_uncertainty_score":0.3248389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005577043534267185,"score_gpt":0.2219715203103723,"score_spread":0.2163944767761052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}