{"id":"W2346415435","doi":"10.1016/j.ijpara.2016.04.004","title":"Interaction of macrocyclic lactones with a Dirofilaria immitis P-glycoprotein","year":2016,"lang":"en","type":"article","venue":"International Journal for Parasitology","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Dirofilaria immitis; Biology; Ivermectin; Moxidectin; Dirofilariasis; Lactone; Rhodamine 123; Biochemistry; Microbiology; Drug resistance; Immunology; Helminths; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139146,0.0002448252,0.000236389,0.00009236158,0.0001850349,0.0002185834,0.0001937378,0.0003056332,0.001885714],"category_scores_gemma":[0.0002892861,0.00009031604,0.0002292047,0.000108089,0.0001157791,0.0001613831,0.0001514885,0.0002756502,0.0003321005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003427627,"about_ca_system_score_gemma":0.0001615455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002194969,"about_ca_topic_score_gemma":0.001757655,"domain_scores_codex":[0.9998664,0.00004210342,0.000005405178,0.00001621562,0.00002155668,0.00004837666],"domain_scores_gemma":[0.9999288,0.0000326713,0.000009607635,0.000003827683,0.000009860003,0.00001507908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004422544,0.0001969089,0.002047231,0.0001740349,0.0000704024,0.0007433498,0.00009708862,0.0008559171,0.981694,0.0002931635,0.0007654329,0.008639792],"study_design_scores_gemma":[0.0002243499,0.008247781,0.01595685,0.00002789568,0.00008736197,0.001256216,0.0002053466,0.004142954,0.9596614,0.0001120744,0.01003735,0.00004048684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960771,0.001990554,0.0002174732,0.0001058433,0.00004728309,0.00001424493,0.0001682419,0.00001472209,0.00136456],"genre_scores_gemma":[0.9976937,0.0007479127,0.0002356408,0.00003977284,0.00001283914,0.000007624872,0.0001556012,0.00000234196,0.001104403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002194969,"threshold_uncertainty_score":0.006308317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222019598605538,"score_gpt":0.4115712639376103,"score_spread":0.3893510679515549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}