{"id":"W2346516822","doi":"10.1093/neuonc/nov221.08","title":"METB-08INHIBITION OF HEXOKINASE 2 USING TUMOR GLYCOLYSIS INHIBITORS IDENTIFIED THROUGH A DRUG SCREEN INHIBITS GLIOBLASTOMA GROWTH IN VITRO AND IN VIVO","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"In vivo; Glioblastoma; Hexokinase; In vitro; Glycolysis; Drug; Pharmacology; Chemistry; Cancer research; Biochemistry; Enzyme; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001015707,0.0005060196,0.000515896,0.0004950322,0.0001294342,0.0003442406,0.000235864,0.0002016724,0.001073701],"category_scores_gemma":[0.00009606989,0.00014438,0.0003135845,0.0003996104,0.0001142977,0.0001262749,0.0001374224,0.0004353258,0.0002180931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003608941,"about_ca_system_score_gemma":0.0002893382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001364002,"about_ca_topic_score_gemma":0.004299225,"domain_scores_codex":[0.9999055,0.00001274595,0.00001138109,0.00001832052,0.00003077193,0.00002136218],"domain_scores_gemma":[0.9999478,0.00001004847,0.00001553681,0.000004937989,0.000009049747,0.0000127061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003498811,0.0002045275,0.0005513104,0.00009718812,0.00003251004,0.00006298108,0.00001104607,0.0004282366,0.9888579,0.00009729867,0.0002335389,0.009073515],"study_design_scores_gemma":[0.0001259334,0.002959874,0.006859127,0.00001621941,0.00008332933,0.0003020207,0.00001997014,0.001742472,0.9846897,0.00004228119,0.003149827,0.000009225945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987056,0.0053861,0.003152295,0.0001986977,0.00005732878,0.0001408238,0.001192572,0.0002183941,0.002597859],"genre_scores_gemma":[0.9869539,0.004937836,0.003434708,0.00009303352,0.00001426236,0.0001092054,0.002164336,0.00002713478,0.002265588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001364002,"threshold_uncertainty_score":0.003591835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664678465682504,"score_gpt":0.2724587597896256,"score_spread":0.2558119751328005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}