{"id":"W2346516822","doi":"10.1093/neuonc/nov221.08","title":"METB-08INHIBITION OF HEXOKINASE 2 USING TUMOR GLYCOLYSIS INHIBITORS IDENTIFIED THROUGH A DRUG SCREEN INHIBITS GLIOBLASTOMA GROWTH IN VITRO AND IN VIVO","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"In vivo; Glioblastoma; Hexokinase; In vitro; Glycolysis; Drug; Pharmacology; Chemistry; Cancer research; Biochemistry; Enzyme; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004503689,0.0002503143,0.0005395147,0.0002787724,0.0000392922,0.0000181627,0.0001437976,0.0002227889,0.00000960253],"category_scores_gemma":[0.0003816583,0.0002723602,0.0001047368,0.0004819043,0.0002080041,0.00003277372,0.0002476194,0.00021939,0.00000178222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001025818,"about_ca_system_score_gemma":0.0003944681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085916,"about_ca_topic_score_gemma":0.001594486,"domain_scores_codex":[0.9978537,0.000352591,0.0005782039,0.0006006201,0.0002116683,0.0004032112],"domain_scores_gemma":[0.9990786,0.00005236091,0.0002776943,0.0002611448,0.0001542214,0.0001759331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001683844,0.0002068531,0.0005036457,0.00003063883,0.00001910642,0.00005646726,0.0006261137,0.00005810771,0.9944111,0.00002723875,0.001452667,0.0009241917],"study_design_scores_gemma":[0.003576409,0.0003955871,0.0002024382,0.00003041167,0.00005233198,0.0001472603,0.0005541492,0.00009321463,0.9821413,0.0001661854,0.01240458,0.0002361633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996334,0.001716199,0.00006390125,0.0001735281,0.0008828982,0.0004072034,0.00005346272,0.00001263011,0.0003561526],"genre_scores_gemma":[0.9978673,0.0002113098,0.0006452085,0.0005529571,0.0005915289,0.00004520548,0.00002331337,0.00003741535,0.00002579965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01226986,"threshold_uncertainty_score":0.9999729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664678465682504,"score_gpt":0.2724587597896256,"score_spread":0.2558119751328005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}