{"id":"W2346557592","doi":"10.1186/s13148-016-0215-4","title":"Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation","year":2016,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Studienstiftung des Deutschen Volkes; Bundesministerium für Bildung und Forschung","keywords":"CTCF; Genomic imprinting; DNA methylation; Biology; Transcription factor; Epigenetics; Imprinting (psychology); Chromatin; CRISPR; Methylation; Genetics; Chromatin immunoprecipitation; Enhancer; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005116112,0.0001422642,0.0001840268,0.00002735506,0.00008691378,0.00001791755,0.0001239545,0.0002210303,0.00007837804],"category_scores_gemma":[0.0004310975,0.0001065871,0.000105893,0.00004736688,0.0002165614,0.000003962089,0.0001025661,0.00006807227,0.00001527107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006881892,"about_ca_system_score_gemma":0.00003262519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004295686,"about_ca_topic_score_gemma":0.00002264955,"domain_scores_codex":[0.9985802,0.0001022343,0.0005398309,0.0004166938,0.0001325921,0.0002284934],"domain_scores_gemma":[0.9992492,0.00008679517,0.0001408362,0.0002848518,0.0001134113,0.0001249655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001393467,0.00005399857,0.07645347,0.00001187094,0.00003807695,4.281945e-7,0.00001561962,0.00001934011,0.8264773,0.0007052185,0.0004391931,0.0957715],"study_design_scores_gemma":[0.001300999,0.0005454466,0.9177619,0.00003960777,0.00003397027,0.000008995771,0.0000117095,0.000125299,0.0511629,0.006182379,0.02257397,0.0002528512],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720106,0.0008169414,0.02559333,0.0008146915,0.0002777763,0.0001382868,0.00001518152,0.00001324834,0.0003199491],"genre_scores_gemma":[0.9935526,0.0009610922,0.003715985,0.0001424887,0.0004414654,0.000008585501,0.00004177044,0.00002231704,0.001113678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8413084,"threshold_uncertainty_score":0.4346495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03547001202568329,"score_gpt":0.3256148072426463,"score_spread":0.290144795216963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}