{"id":"W2346561278","doi":"10.1074/jbc.m115.697300","title":"Competitive Inhibition of Lysine Acetyltransferase 2B by a Small Motif of the Adenoviral Oncoprotein E1A","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Project 985; National Natural Science Foundation of China","keywords":"PCAF; Histone acetyltransferase; Acetyltransferase; Acetylation; Biology; Histone; P300-CBP Transcription Factors; Molecular biology; Histone Acetyltransferases; Histone H3; Sequence motif; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656224,0.0003249246,0.0002406917,0.0000891597,0.0001109777,0.0001765112,0.0002652392,0.0001894925,0.001059281],"category_scores_gemma":[0.0001291731,0.0001210102,0.0002573652,0.00009428901,0.0001678556,0.0001330626,0.0001898245,0.0004606078,0.0002836315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003212932,"about_ca_system_score_gemma":0.0002285729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006208107,"about_ca_topic_score_gemma":0.0009149949,"domain_scores_codex":[0.999863,0.00002484665,0.00001216163,0.00003181813,0.00003607139,0.00003196025],"domain_scores_gemma":[0.9999236,0.00002186938,0.00001813531,0.00001111561,0.00000621122,0.00001906957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001717133,0.00005470236,0.0001253501,0.00002549866,0.00000749896,0.00001781007,0.000004980866,0.0001054221,0.9985656,0.0001137007,0.00002024015,0.0007874451],"study_design_scores_gemma":[0.00002192425,0.000468126,0.0007610742,0.000002603689,0.000009125233,0.00007771552,0.000004779554,0.001481626,0.9962347,0.00002,0.0009155922,0.000002686656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956025,0.000988067,0.002265553,0.00003433537,0.00002671273,0.00002407915,0.00009762729,0.00003120564,0.0009300327],"genre_scores_gemma":[0.9964228,0.000358436,0.002060584,0.00002330979,0.000005526896,0.00002750832,0.0002031514,0.000007331617,0.0008911735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059281,"threshold_uncertainty_score":0.003543675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887852655632214,"score_gpt":0.2598987607451396,"score_spread":0.2410202341888174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}