{"id":"W2346578725","doi":"10.1371/journal.pone.0154589","title":"The Human Sodium-Glucose Cotransporter (hSGLT1) Is a Disulfide-Bridged Homodimer with a Re-Entrant C-Terminal Loop","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cysteine; Cotransporter; Chemistry; Förster resonance energy transfer; Biophysics; Xenopus; Transmembrane protein; Transmembrane domain; Membrane potential; Fluorescence; Biochemistry; Fluorophore; Membrane; Sodium; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061858,0.0001908759,0.0001650574,0.0001208924,0.0001332523,0.0002154503,0.0001625495,0.0002770638,0.00103487],"category_scores_gemma":[0.00007771621,0.00007423534,0.0001797438,0.0001520688,0.0001839266,0.0001436399,0.0001440654,0.000257336,0.0006084029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002510178,"about_ca_system_score_gemma":0.0001038612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003041829,"about_ca_topic_score_gemma":0.0002135568,"domain_scores_codex":[0.9999069,0.00001599391,0.000007430559,0.00003756078,0.00002287937,0.000009235282],"domain_scores_gemma":[0.9999653,0.000003808759,0.00001063437,0.000004273234,0.000005796421,0.00001015297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001360857,0.00001589611,0.0007479045,0.00004912929,0.000008928919,0.000102078,0.00002645529,0.00007800791,0.9937784,0.0003034078,0.0002582,0.00449542],"study_design_scores_gemma":[0.00004092322,0.0003133606,0.01057523,0.000009074075,0.00002624884,0.001770954,0.0000530649,0.002658287,0.9607183,0.0003321342,0.02348944,0.00001306217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840091,0.003067115,0.009249858,0.0003983015,0.00009475565,0.00003731719,0.0007195807,0.0002776853,0.002146199],"genre_scores_gemma":[0.9850025,0.001100447,0.007152007,0.0001243044,0.00002441973,0.00002915307,0.001414288,0.00001769594,0.005135353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103487,"threshold_uncertainty_score":0.003461957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03088811024124074,"score_gpt":0.2359083533238977,"score_spread":0.2050202430826569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}