{"id":"W2346584176","doi":"10.1021/acs.biochem.5b01285","title":"Mechanism of Human Nucleocytoplasmic Hexosaminidase D","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Directorate-General for Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Agentúra na Podporu Výskumu a Vývoja; Canada Research Chairs; Slovenská Akadémia Vied; Wellcome Trust; Wellcome","keywords":"Chemistry; Enzyme; Residue (chemistry); Hexosaminidase; Biochemistry; Mutant; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008505875,0.0002333226,0.0002762661,0.00002145234,0.0000692292,0.00001244336,0.0003642831,0.0002701779,0.005119069],"category_scores_gemma":[0.0001180386,0.0001834074,0.0001855442,0.00007625084,0.0001699786,0.0000488221,0.0001021712,0.00009214855,0.00004308396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008549502,"about_ca_system_score_gemma":0.00005724701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007651001,"about_ca_topic_score_gemma":5.838622e-7,"domain_scores_codex":[0.9987067,0.000006261449,0.0003645469,0.000398633,0.0002293242,0.0002945489],"domain_scores_gemma":[0.9987909,0.0001046717,0.0001821888,0.0007089722,0.00006488215,0.0001483438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001930355,0.00008591765,0.0002318074,0.0002470778,0.00003812537,0.00001667524,0.00002065488,2.992342e-8,0.9975443,0.0004358203,0.0004051529,0.0009551122],"study_design_scores_gemma":[0.0005158051,0.000008524161,0.000007962234,0.0002046967,0.00002922032,0.00002295099,0.00008948953,0.000004268409,0.9976434,0.0007751961,0.0004321147,0.0002663373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492196,0.00005366993,0.00002302122,0.0001080375,0.00003440054,0.00001956746,0.0001371913,0.0001055911,0.05029893],"genre_scores_gemma":[0.9901171,0.00001709896,0.00007642945,0.00001624194,0.0001947099,0.0000146084,0.00002136468,0.00003211321,0.009510385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04089745,"threshold_uncertainty_score":0.9957904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373756160097291,"score_gpt":0.2252028765317191,"score_spread":0.2114653149307462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}