{"id":"W2346584176","doi":"10.1021/acs.biochem.5b01285","title":"Mechanism of Human Nucleocytoplasmic Hexosaminidase D","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Directorate-General for Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Agentúra na Podporu Výskumu a Vývoja; Canada Research Chairs; Slovenská Akadémia Vied; Wellcome Trust; Wellcome","keywords":"Chemistry; Enzyme; Residue (chemistry); Hexosaminidase; Biochemistry; Mutant; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083507,0.0004279544,0.000279651,0.0002070039,0.0001902152,0.0005829731,0.0004372062,0.0004576951,0.0009153102],"category_scores_gemma":[0.0001878841,0.0001570685,0.0003229173,0.0001058367,0.0004001333,0.0003222807,0.0002973534,0.0003280299,0.0006442275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006489506,"about_ca_system_score_gemma":0.0004038115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005002367,"about_ca_topic_score_gemma":0.0001678503,"domain_scores_codex":[0.9998049,0.00003995092,0.00001347484,0.00007248991,0.00003992609,0.00002923008],"domain_scores_gemma":[0.9999421,0.00001478811,0.00001223461,0.00000997739,0.00001006139,0.00001083551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004442912,0.00006285028,0.002264459,0.0002371214,0.00002759476,0.0007467624,0.00008256252,0.0008396425,0.973075,0.008229254,0.000524735,0.01346564],"study_design_scores_gemma":[0.00003472251,0.000241817,0.001273581,0.00001385432,0.00001655761,0.001626594,0.0000486813,0.003586475,0.9803528,0.001006015,0.0117827,0.00001610867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8810019,0.02136105,0.08180422,0.0009653055,0.0002607632,0.0003442165,0.0005822808,0.000367519,0.01331264],"genre_scores_gemma":[0.9834492,0.003665668,0.008461646,0.000227469,0.00002005485,0.00006240198,0.0003392556,0.0000118062,0.003762433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009153102,"threshold_uncertainty_score":0.004708469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373756160097291,"score_gpt":0.2252028765317191,"score_spread":0.2114653149307462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}